ArticleGenetics1994
The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
- Different genetic basis for alcohol dehydrogenase activity and plasticity in a novel alcohol environment for Drosophila melanogaster.Heredity · 2020Article
- Analysis of Four Polymorphisms Located at the Promoter of the Estrogen Receptor Alpha ESR1 Gene in a Population With Gender Incongruence.Sexual medicine · 2020Article
- Fitness effects but no temperature-mediated balancing selection at the polymorphicProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A major role for noncoding regulatory mutations in the evolution of enzyme activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility ofGenetics · 2017Article
- Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.Nature ecology & evolution · 2017Article
- Dissecting complex traits using the Drosophila Synthetic Population Resource.Trends in genetics : TIG · 2014Review
- Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.Genome research · 2012Article
- Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion.Genetics · 2012Article
- Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution.Methods in molecular biology (Clifton, N.J.) · 2011Review
- Alcohol dehydrogenase activities and ethanol tolerance in Anastrepha (Diptera, Tephritidae) fruit-fly species and their hybrids.Genetics and molecular biology · 2009Article
- PvuII polymorphism of estrogen receptor-α gene in breast cancer.Indian journal of human genetics · 2007Article
- Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology.BMC genetics · 2005Article
- Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus.Annals of the rheumatic diseases · 2004Article
- Functional analysis of Drosophila melanogaster gene regulatory sequences by transgene coplacement.Genetics · 2004Article
- Molecular basis of the size polymorphism of the first intron of the Adh-1 gene of the mediterranean fruit fly, Ceratitis capitata.Journal of molecular evolution · 2004Article
- Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila.Genetics · 2003Article
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- A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression.Genetics · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence indicate that natural selection controls the frequencies of an allozyme polymorphism at the alcohol dehydrogenase (Adh) locus in Drosophila melanogaster. However, because of associations among sequence polymorphisms in the Adh region, it is not clear whether selection acts directly (or solely) on the allozymic site. This problem has been approached by using in vitro mutagenesis to distinguish among the effects on Adh expression of individual polymorphisms. This study shows that a polymorphism within the first Adh intron (delta 1) has a significant effect on the level of ADH protein. Like the allozyme, delta 1 shows a geographic cline in frequency, indicating that it may also be a target of natural selection. These results suggest that multisite selection models may be required to understand the evolutionary dynamics of individual loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.