ArticleThe EMBO journal1995
Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- The human branchpoint-interacting stem loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and transcriptome.bioRxiv : the preprint server for biology · 2025Article
- PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2.NPJ genomic medicine · 2022Article
- Emerging roles of macrosatellite repeats in genome organization and disease development.Epigenetics · 2017Review
- Regulation of Cellular Dynamics and Chromosomal Binding Site Preference of Linker Histones H1.0 and H1.X.Molecular and cellular biology · 2016Article
- Structure and Organization of the Engraulidae Family U2 snRNA: An Evolutionary Model Gene?Journal of molecular evolution · 2015Article
- Developmental analysis of spliceosomal snRNA isoform expression.G3 (Bethesda, Md.) · 2014Article
- Human snRNA genes use polyadenylation factors to promote efficient transcription termination.Nucleic acids research · 2014Article
- Article
- Direct visualization of the highly polymorphic RNU2 locus in proximity to the BRCA1 gene.PloS one · 2013Article
- Nuclear domain 10-associated proteins recognize and segregate intranuclear DNA/protein complexes to negate gene expression.Virology journal · 2012Article
- Genetic characterization of Plectorhinchus mediterraneus yields important clues about genome organization and evolution of multigene families.BMC genetics · 2012Article
- Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration.Cell · 2012Article
- Evolution of ribosomal DNA-derived satellite repeat in tomato genome.BMC plant biology · 2009Article
- Human U2 snRNA genes exhibit a persistently open transcriptional state and promoter disassembly at metaphase.Molecular and cellular biology · 2008Article
- Similar active genes cluster in specialized transcription factories.The Journal of cell biology · 2008Article
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
- Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.Antimicrobial agents and chemotherapy · 2004Article
- The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.The EMBO journal · 2003Article
- Novel design architecture for genetic stability of recombinant poliovirus: the manipulation of G/C contents and their distribution patterns increases the genetic stability of inserts in a poliovirus-based RPS-Vax vector system.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In primates, the tandemly repeated genes encoding U2 small nuclear RNA evolve concertedly, i.e. the sequence of the U2 repeat unit is essentially homogeneous within each species but differs somewhat between species. Using chromosome painting and the NGFR gene as an outside marker, we show that the U2 tandem array (RNU2) has remained at the same chromosomal locus (equivalent to human 17q21) through multiple speciation events over > 35 million years leading to the Old World monkey and hominoid lineages. The data suggest that the U2 tandem repeat, once established in the primate lineage, contained sequence elements favoring perpetuation and concerted evolution of the array in situ, despite a pericentric inversion in chimpanzee, a reciprocal translocation in gorilla and a paracentric inversion in orang utan. Comparison of the 11 kb U2 repeat unit found in baboon and other Old World monkeys with the 6 kb U2 repeat unit in humans and other hominids revealed that an ancestral U2 repeat unit was expanded by insertion of a 5 kb retrovirus bearing 1 kb long terminal repeats (LTRs). Subsequent excision of the provirus by homologous recombination between the LTRs generated a 6 kb U2 repeat unit containing a solo LTR. Remarkably, both junctions between the human U2 tandem array and flanking chromosomal DNA at 17q21 fall within the solo LTR sequence, suggesting a role for the LTR in the origin or maintenance of the primate U2 array.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.