ArticleThe EMBO journal1995
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 111 citations in OpenAlex.
- A novel inducible haematopoietic cell-depleting mouse model for chimeric complementation of blood cells.Cell proliferation · 2023Article
- Epigenetic modifier SMCHD1 maintains a normal pool of long-term hematopoietic stem cells.iScience · 2022Article
- New transgenic mouse models enabling pan-hematopoietic or selective hematopoietic stem cell depletion in vivo.Scientific reports · 2022Article
- Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis.Frontiers in endocrinology · 2022Review
- SNARE protein SEC22B regulates early embryonic development.Scientific reports · 2019Article
- Bone marrow adipocytes.Adipocyte · 2017Review
- Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic reporter gene.Experimental hematology · 2016Article
- Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.PloS one · 2015Article
- Article
- Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo.International journal of hematology · 2002Review
- Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.Molecular and cellular biology · 2001Article
- Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.The Biochemical journal · 2000Article
- Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes.Molecular and cellular biology · 1998Article
- Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila.Genes & development · 1998Article
- A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.Molecular and cellular biology · 1997Article
- p95vav associates with the nuclear protein Ku-70.Molecular and cellular biology · 1996Article
- A functional T-cell receptor signaling pathway is required for p95vav activity.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have suggested that the vav protooncogene plays an important role in hematopoiesis. To study this further, we have ablated the vav protooncogene by homologous recombination in embryonic stem (ES) cells. Homozygous vav (-/-) ES clones differentiate normally in culture and generate cells of erythroid, myeloid and mast cell lineages. Mice heterozygous for the targeted vav allele do not display any obvious abnormalities. However, homozygous embryos die very early during development. Crosses of vav (+/-) heterozygous mice yield apparently normal vav (-/-) E3.5 embryos but not post-implantation embryos (> or = E7.5). Furthermore, homozygous vav (-/-) blastocysts do not hatch in vitro. These results indicate that vav is essential for an early developmental step(s) that precedes the onset of hematopoiesis. Consistent with the phenotypic analysis of vav (-/-) embryos, we have identified Vav immunoreactivity in the extra-embryonic trophoblastic cell layer but not in the inner embryonic cell mass of E3.5 preimplantation embryos or in the egg cylinder of E6.5 and E7.5 post-implantation embryos. These results suggest that the vav gene is essential for normal trophoblast development and for implantation of the developing embryo.
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