ArticleAmerican journal of human genetics1995
Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 68 citations in OpenAlex.
- Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families.Journal of lipid research · 2019Article
- Structure, function, and genetics of lipoprotein (a).Journal of lipid research · 2016Review
- Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.Journal of lipid research · 2009 · on this mapArticle
- Biochemical correlates of lipoprotein(a) in a general adult population. Possible implications for cardiovascular risk assessment.Journal of thrombosis and thrombolysis · 2009Article
- A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription.The Biochemical journal · 2004Article
- Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers.The Biochemical journal · 2002Article
- The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.American journal of human genetics · 1997Article
- Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB.The Journal of clinical investigation · 1997Article
- The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lipoprotein (a) (Lp[a]) is a cholesterol-rich lipoprotein resembling LDL but also containing a large polypeptide designated apolipoprotein (a) (apo[a]). Its levels are highly variable among individuals and, in a number of studies, are strongly correlated with the risk of coronary artery disease (CAD). In an effort to determine which genes control Lp(a) levels, we have studied 25 multiplex families (comprising 298 members) enriched for CAD. The apo(a) gene was genotyped among the families, using a highly informative pulse-field gel electrophoresis procedure. In addition, polymorphisms of the gene for the other major protein of Lp(a), apolipoprotein B (apoB), were examined. Quantitative sib-pair linkage analysis indicates that apo(a) is the major gene controlling Lp(a) levels in this CAD population (P = .001; 99 sib pairs), whereas the apoB gene demonstrated no significant quantitative linkage effect. We estimate that the apo(a) locus accounts for < or = 98% of variance of Lp(a) serum levels. Approximately 43% of this variation is explained by size polymorphisms within the apo(a) gene. These results indicate that the apo(a) gene is the major determinant of Lp(a) serum levels not only in the general population but also in a high-risk CAD population.
Indexed as
Identifiers
7825589PMC1801290W2993032494What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.