ArticleAmerican journal of human genetics1995
An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Common BRCA1 and BRCA2 mutations in breast cancer families: a meta-analysis from systematic review.Molecular biology reports · 2012Pooled it
- Breast, ovarian, and endometrial malignancies in systemic lupus erythematosus: a meta-analysis.British journal of cancer · 2011Pooled it
- The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis.Antioxidants (Basel, Switzerland) · 2022Review
- Summary of Utah Project on Exfoliation Syndrome (UPEXS): using a large database to identify systemic comorbidities.BMJ open ophthalmology · 2021Review
- Pathogenic germlineJCO precision oncology · 2018Article
- Simultaneous detection of genetic and copy number alterations inOncotarget · 2017Article
- Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary Breast and Ovarian Cancer) to the Brain, Diagnosed at 18 Weeks' Gestation: A Case Report and Review of the Literature.Case reports in obstetrics and gynecology · 2016Article
- Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer.Molecular genetics & genomic medicine · 2015Article
- Promoter methylation and expression changes ofOncology letters · 2015Article
- Detection of BRCA1 and BRCA2 germline mutations in Japanese population using next-generation sequencing.Molecular genetics & genomic medicine · 2015Article
- Phenotypic heterogeneity of hereditary gynecologic cancers: a report from the Creighton hereditary cancer registry.Familial cancer · 2013Article
- Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer.PloS one · 2013Article
- Analysis of BRCA1 Gene Rearrangements in Breast Carcinomas by RT-PCR and ER, PR, HER2NEU Status by IHC and HPE Correlation.Journal of clinical and diagnostic research : JCDR · 2012Article
- BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.Molecular biology reports · 2012Article
- Modern trends into the epidemiology and screening of ovarian cancer. Genetic substrate of the sporadic form.Pathology oncology research : POR · 2012Review
- Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.Carcinogenesis · 2012Article
- Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.PloS one · 2012Article
- The occurrence of germline BRCA1 and BRCA2 sequence alterations in Slovenian population.BMC medical genetics · 2011Article
- Novel genetic variants in miR-191 gene and familial ovarian cancer.BMC cancer · 2010Article
- Management of the asymptomatic BRCA mutation carrier.The application of clinical genetics · 2010Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The breast-ovary cancer-family syndrome is a dominant predisposition to cancer of the breast and ovaries which has been mapped to chromosome region 17q12-q21. The majority, but not all, of breast-ovary cancer families show linkage to this susceptibility locus, designated BRCA1. We report here the results of a linkage analysis of 145 families with both breast and ovarian cancer. These families contain either a total of three or more cases of early-onset (before age 60 years) breast cancer or ovarian cancer. All families contained at least one case of ovarian cancer. Overall, an estimated 76% of the 145 families are linked to the BRCA1 locus. None of the 13 families with cases of male breast cancer appear to be linked, but it is estimated that 92% (95% confidence interval 76%-100%) of families with no male breast cancer and with two or more ovarian cancers are linked to BRCA1. These data suggest that the breast-ovarian cancer-family syndrome is genetically heterogeneous. However, the large majority of families with early-onset breast cancer and with two or more cases of ovarian cancer are likely to be due to BRCA1 mutations.
Indexed as
Identifiers
7825586PMC1801289W1550117782What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.