ArticleAmerican journal of human genetics1995
Likelihood methods for locating disease genes in nonequilibrium populations.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- A novel intronic mutation ofMolecular vision · 2019Article
- Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory.Frontiers in genetics · 2016Article
- Bayesian model selection for multiple QTLs mapping combining linkage disequilibrium and linkage.Genetics research · 2014Article
- Review
- A fast expectation-maximum algorithm for fine-scale QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- The effects of inbreeding, genetic dissimilarity and phenotype on male reproductive success in a dioecious plant.Proceedings. Biological sciences · 2012Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data.Genetics · 2005Article
- Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.Genes and immunity · 2005Article
- Simultaneous detection of linkage disequilibrium and genetic differentiation of subdivided populations.Genetics · 2004Article
- Detecting population growth, selection and inherited fertility from haplotypic data in humans.Genetics · 2003Article
- The extent of linkage disequilibrium and haplotype sharing around a polymorphic site.Genetics · 2003Article
- Theory of the effects of population structure and sampling on patterns of linkage disequilibrium applied to genomic data from humans.Genetics · 2003Article
- Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework.Genetics · 2003Article
- Homozygosity and linkage disequilibrium.Genetics · 2002Article
- Score tests for association between traits and haplotypes when linkage phase is ambiguous.American journal of human genetics · 2002Article
- Molecular analysis of the beta-globin gene cluster in the Niokholo Mandenka population reveals a recent origin of the beta(S) Senegal mutation.American journal of human genetics · 2002Article
- Bayesian analysis of haplotypes for linkage disequilibrium mapping.Genome research · 2001Article
- Article
- High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence.American journal of human genetics · 2001Article
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Abstract
Until recently, attempts to map disease genes on the basis of population associations with linked markers have been based on expected values of linkage disequilibrium. These methods suffer from the large variances imposed on disequilibrium measures by the evolutionary process, but a more serious problem for many diseases is that they assume an equilibrium population. For diseases that arose only a few hundred generations ago, it is more appropriate to concentrate on the initial growth phase of the disease. We invoke a Poisson branching process for this early growth, and estimate the likelihood for the recombination fraction between marker and disease loci, on the basis of simulated disease populations. The limits of the resulting support intervals for the recombination fraction vary inversely with the age of the disease in generations. We illustrate the procedure with data on cystic fibrosis and diastrophic dysplasia, for which the method appears appropriate, and for Friedreich ataxia and Huntington disease, for which it does not. A valuable aspect of the method is the ability in some cases to compare likelihoods of the three orders for a disease locus and two linked marker loci.
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