Evidence map›Paper›PMID 7824037›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology1994

5-Hydroxytryptamine (5-HT) and the initiation of migraine: new perspectives.

J R Fozard, H O Kalkman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Functional 5-HT receptors in human occipital artery.Naunyn-Schmiedeberg's archives of pharmacology · 2004
    Article
  12. The role of nitric oxide in vascular headache.Pharmacy world & science : PWS · 2003
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The autonomic nervous system and the regulation of arterial tone in migraine.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 1995
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J R FozardPreclinical Research, Sandoz Pharma Ltd., Basel, Switzerland.
H O Kalkman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HT2C receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache. Taken together the data bring new perspectives to the role of 5-HT acting through 5-HT2C (or closely similar) receptors in the initiation of migraine.

Indexed as

AnimalsHumansMigraine DisordersReceptors, SerotoninSerotoninReceptors, SerotoninSerotonin

Identifiers

PMID7824037
OpenAlexW2000979352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.