ArticleMolecular and cellular biology1995
Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 146 citations in OpenAlex.
- Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression.International journal of molecular sciences · 2026Review
- Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Direct Conversion of Human Urine Cells to Neurons by Small Molecules.Scientific reports · 2019Article
- Stage-specific roles of Ezh2 and Retinoic acid signaling ensure calvarial bone lineage commitment.Developmental biology · 2018Article
- Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.The Journal of biological chemistry · 2018Article
- Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales.Molecular neurobiology · 2018Article
- RARα and RARγ reciprocally control K5Organogenesis · 2017Article
- Radiolabeling and initial biological evaluation of [Bioorganic & medicinal chemistry letters · 2017Article
- Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2015Article
- Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons.The Journal of biological chemistry · 2014Article
- Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.Nucleic acids research · 2013Article
- Article
- CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.Cell cycle (Georgetown, Tex.) · 2013Article
- RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.Journal of cell science · 2013Article
- Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.Nucleic acids research · 2012Article
- Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.ACS chemical biology · 2011Article
- Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A.BMC developmental biology · 2011Article
- Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.PloS one · 2010Article
- All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.PloS one · 2010Article
- Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.Biochemical pharmacology · 2008Article
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
F9 embryonic teratocarcinoma stem cells differentiate into an epithelial cell type called extraembryonic endoderm when treated with retinoic acid (RA), a derivative of retinol (vitamin A). This differentiation is presumably mediated through the actions of retinoid receptors, the RARs and RXRs. To delineate the functions of each of the different retinoid receptors in this model system, we have generated F9 cell lines in which both copies of either the RAR alpha gene or the RAR gamma gene are disrupted by homologous recombination. The absence of RAR alpha is associated with a reduction in the RA-induced expression of both the CRABP-II and Hoxb-1 (formerly 2.9) genes. The absence of RAR gamma is associated with a loss of the RA-inducible expression of the Hoxa-1 (formerly Hox-1.6), Hoxa-3 (formerly Hox-1.5), laminin B1, collagen IV (alpha 1), GATA-4, and BMP-2 genes. Furthermore, the loss of RAR gamma is associated with a reduction in the metabolism of all-trans-RA to more polar derivatives, while the loss of RAR alpha is associated with an increase in metabolism of RA relative to wild-type F9 cells. Thus, each of these RARs exhibits some specificity with respect to the regulation of differentiation-specific gene expression. These results provide an explanation for the expression of multiple RAR types within one cell type and suggest that each RAR has specific functions.
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