ArticleMolecular and cellular biology1995
AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Beyond division and morphogenesis: Considering the emerging roles of septins in plasma membrane homeostasis and cell wall integrity in human fungal pathogens.PLoS pathogens · 2025Article
- Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.Eukaryotic cell · 2008Article
- Article
- Article
- Sterol-rich plasma membrane domains in fungi.Eukaryotic cell · 2007Review
- The yeast actin cytoskeleton: from cellular function to biochemical mechanism.Microbiology and molecular biology reviews : MMBR · 2006Review
- Septin function in yeast model systems and pathogenic fungi.Eukaryotic cell · 2005Review
- The Glc7p-interacting protein Bud14p attenuates polarized growth, pheromone response, and filamentous growth in Saccharomyces cerevisiae.Eukaryotic cell · 2002Article
- Candida albicans Int1p interacts with the septin ring in yeast and hyphal cells.Molecular biology of the cell · 2001Article
- Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function.The Journal of cell biology · 1998Article
- Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton.The Journal of cell biology · 1998Article
- Pheromone-regulated genes required for yeast mating differentiation.The Journal of cell biology · 1998Article
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- A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall.The Journal of cell biology · 1997Article
- Functional analysis of the interaction between Afr1p and the Cdc12p septin, two proteins involved in pheromone-induced morphogenesis.Molecular biology of the cell · 1997Article
- Article
- Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation.Molecular and cellular biology · 1996Article
- Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.The Journal of cell biology · 1995Article
- Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae.Microbiological reviews · 1995Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The G protein-coupled alpha-factor receptor promotes polarized growth toward a mating partner. alpha-Factor induces the expression of AFR1, which acts together with the receptor C terminus to promote normal morphogenesis. The function of AFR1 was investigated by engineering cells to constitutively express AFR1 without alpha-factor. Constitutive AFR1 expression caused cells to form elongated buds that demonstrate that AFR1 can also interact with the morphogenesis components that promote bud formation. A similar elongated bud phenotype is caused by mutation of the CDC3, CDC10, CDC11, and CDC12 genes, which encode putative filament proteins that form a ring at the bud neck. AFR1 may act directly on the filament proteins, since immunolocalization detected AFR1 at the bud neck and interaction of AFR1 and CDC12 was detected in the two-hybrid protein assay. AFR1 localized to the base of pheromone-induced projections. These results suggest that AFR1 and the putative filament proteins act together with the receptor to facilitate proper localization of components during mating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.