ArticleMolecular and cellular biology1995
PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed.
- Review
- Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species.Pathogens (Basel, Switzerland) · 2025Review
- Vaginal Candida albicans infections: host-pathogen-microbiome interactions.FEMS microbiology reviews · 2025Review
- Article
- Article
- A glycosylated Phr1 protein is induced by calcium stress and its expression is positively controlled by the calcium/calcineurin signaling transcription factor Crz1 in Candida albicans.Cell communication and signaling : CCS · 2023Article
- Fungal resilience and host-pathogen interactions: Future perspectives and opportunities.Parasite immunology · 2023Review
- The Role of Glycoside Hydrolases in S. gordonii and C. albicans Interactions.Applied and environmental microbiology · 2022Article
- Update on the Pathogenesis, Virulence, and Treatment ofPathogens & immunity · 2022Review
- Article
- Candida albicans promotes tooth decay by inducing oral microbial dysbiosis.The ISME journal · 2021Article
- Exogenous Reproductive Hormones nor Candida albicans Colonization Alter the Near Neutral Mouse Vaginal pH.Infection and immunity · 2021Article
- pH Changes Have a Profound Effect on Gene Expression, Hydrolytic Enzyme Production, and Dimorphism inFrontiers in microbiology · 2021Article
- The regulation of hyphae growth inVirulence · 2020Review
- Multicellular growth of the Basidiomycota phytopathogen fungus Sporisorium reilianum induced by acid conditions.Folia microbiologica · 2020Article
- Transcriptome analysis of the dimorphic transition induced by pH change and lipid biosynthesis in Trichosporon cutaneum.Journal of industrial microbiology & biotechnology · 2020Article
- Protein markers forJournal of extracellular vesicles · 2020Article
- Off the wall: The rhyme and reason ofCell surface (Amsterdam, Netherlands) · 2019Review
- The Glucan-Remodeling Enzyme Phr1p and the Chitin Synthase Chs1p Cooperate to Maintain Proper Nuclear Segregation and Cell Integrity inFrontiers in cellular and infection microbiology · 2019Article
- Physical Interaction of Sodium Houttuyfonate With β-1,3-Glucan EvokesFrontiers in microbiology · 2019Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Candida albicans, like many fungi, exhibits morphological plasticity, a property which may be related to its biological capacity as an opportunistic pathogen of humans. Morphogenesis and alterations in cell shape require integration of many cellular functions and occur in response to environmental signals, most notably pH and temperature in the case of C. albicans. In the course of our studies of differential gene expression associated with dimorphism of C. albicans, we have isolated a gene, designated PHR1, which is regulated in response to the pH of the culture medium. PHR1 expression was repressed at pH values below 5.5 and induced at more alkaline pH. The predicted amino acid sequence of the PHR1 protein was 56% identical to that of the Saccharomyces cerevisiae Ggp1/Gas1 protein, a highly glycosylated cell surface protein attached to the membrane via glycosylphosphatidylinositol. A homozygous null mutant of PHR1 was constructed and found to exhibit a pH-conditional morphological defect. At alkaline pH, the mutant, unlike the parental type, was unable to conduct apical growth of either yeast or hyphal growth forms. This morphological aberration was not associated with defective cytoskeletal polarization or secretion. The results suggest that PHR1 defines a novel function required for apical cell growth and morphogenesis.
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