ArticleInfection and immunity1995
A tissue culture bilayer model to study the passage of Neisseria meningitidis.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Interaction ofFrontiers in cellular and infection microbiology · 2024Article
- A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni.PLoS pathogens · 2020Article
- Physiologically relevant human tissue models for infectious diseases.Drug discovery today · 2016Review
- A Diffusion-Based and Dynamic 3D-Printed Device That Enables Parallel in Vitro Pharmacokinetic Profiling of Molecules.Analytical chemistry · 2016Article
- Hyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease.PLoS pathogens · 2015Article
- Ultrathin Ceramic Membranes as Scaffolds for Functional Cell Coculture Models on a Biomimetic Scale.BioResearch open access · 2015Article
- Serogroup-specific interaction of Neisseria meningitidis capsular polysaccharide with host cell microtubules and effects on tubulin polymerization.Infection and immunity · 2014Article
- State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.ALTEX · 2014Review
- Article
- Late repression of NF-κB activity by invasive but not non-invasive meningococcal isolates is required to display apoptosis of epithelial cells.PLoS pathogens · 2011Article
- Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium.Infection and immunity · 2010Article
- Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis.PLoS pathogens · 2009Article
- Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili, and PorA by Neisseria meningitidis in vivo.Infection and immunity · 2002Article
- An in vitro tissue culture bilayer model to examine early events in Mycobacterium tuberculosis infection.Infection and immunity · 1999Article
- Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.The Journal of clinical investigation · 1998Article
- Transcellular passage of Neisseria gonorrhoeae involves pilus phase variation.Infection and immunity · 1998Article
- Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells.Infection and immunity · 1997Article
- Traversal of a polarized epithelium by pathogenic Neisseriae: facilitation by type IV pili and maintenance of epithelial barrier function.Molecular medicine (Cambridge, Mass.) · 1996Article
- Comparison of in vitro models for the study of Mycobacterium tuberculosis invasion and intracellular replication.Infection and immunity · 1996Article
- Intracellular growth and cytotoxicity of Mycobacterium haemophilum in a human epithelial cell line (Hec-1-B).Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A tissue culture bilayer system has been developed as a model to study the mechanisms of attachment and invasion involved in the pathogenesis of Neisseria meningitidis. The model incorporates epithelial and endothelial cell layers separated by a microporous membrane and makes it possible to observe and quantify the passage of bacteria through the multiple layers and to study the mechanisms by which they make this passage. This model is adaptable to a wide variety of microbial pathogens and can be modified by substituting any physiologically relevant eucaryotic cells for the component layers. The system's makeup of cells of human origin and its reproducibility give it advantages over animal and primary organ culture models, while the added complexity of multiple layers allowing cell-to-cell communication makes it a more realistic human tissue model than standard cell monolayers.
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