ReviewDiabetologia1994
Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases.
Review in Diabetologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 107 citations in OpenAlex.
- Insulin Signaling in Alzheimer's Disease: Association with Brain Insulin Resistance.International journal of molecular sciences · 2026Review
- Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling.Structure (London, England : 1993) · 2025Article
- Changes in Cells Associated with Insulin Resistance.International journal of molecular sciences · 2024Review
- Insulin: A connection between pancreatic β cells and the hypothalamus.World journal of diabetes · 2023Review
- Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion.Biomolecules · 2023Review
- From glucose sensing to exocytosis: takes from maturity onset diabetes of the young.Frontiers in endocrinology · 2023Review
- Isolation and Proteomics of the Insulin Secretory Granule.Metabolites · 2021Review
- Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.The Journal of clinical investigation · 2021Review
- Article
- Insulin: Trigger and Target of Renal Functions.Frontiers in cell and developmental biology · 2020Review
- The cell biology of systemic insulin function.The Journal of cell biology · 2018Review
- Article
- Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis.Journal of diabetes research · 2015Review
- Advances in management of type 1 diabetes mellitus.World journal of diabetes · 2014Review
- Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia.Translational psychiatry · 2014Article
- BIG3 inhibits insulin granule biogenesis and insulin secretion.EMBO reports · 2014Article
- Plasma membrane events associated with the meiotic divisions in the amphibian oocyte: insights into the evolution of insulin transduction systems and cell signaling.BMC developmental biology · 2013Article
- Proteomic profiling in schizophrenia: enabling stratification for more effective treatment.Genome medicine · 2013Review
- Parameters measuring beta-cell function are only valuable in diabetic subjects with low body mass index, high blood glucose level, or long-standing diabetes.Yonsei medical journal · 2011Article
- Fentanyl inhibits glucose-stimulated insulin release from beta-cells in rat pancreatic islets.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies of the post-translational processing of proinsulin and of other proteins which are stored in the granule, particularly the processing enzymes themselves. The present review focusses on recent insights into the molecular nature of the processing machinery, and the granule Ca(2+)-dependent subtilisin-related endopeptidases which catalyse the initial rate-limiting step in the enzymic conversion of proinsulin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.