ReviewDiabetologia1994
Short-term regulation of glucokinase.
Review in Diabetologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment.The Journal of clinical investigation · 2025Review
- Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency.Molecular metabolism · 2024Article
- Are all sugars equal? Role of the food source in physiological responses to sugars with an emphasis on fruit and fruit juice.European journal of nutrition · 2024Review
- Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications.Frontiers in endocrinology · 2023Article
- Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD.Frontiers in endocrinology · 2023Review
- Molecular aspects of fructose metabolism and metabolic disease.Cell metabolism · 2021Review
- Ischemic preconditioning maintains the immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia.Molecular medicine reports · 2015Article
- Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies.Journal of genetics · 2014Review
- Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.Biochimica et biophysica acta · 2014Article
- A fresh view of glycolysis and glucokinase regulation: history and current status.The Journal of biological chemistry · 2014Review
- Serum C-peptide assay of patients with hyperglycemic emergencies at the Lagos State University Teaching Hospital (LASUTH), Ikeja.International archives of medicine · 2014Article
- Time-course changes in immunoreactivities of glucokinase and glucokinase regulatory protein in the gerbil hippocampus following transient cerebral ischemia.Neurochemical research · 2013Article
- Decreased glucokinase protein expression in the aged gerbil hippocampus.Cellular and molecular neurobiology · 2013Article
- Conformational transition pathway in the activation process of allosteric glucokinase.PloS one · 2013Article
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- Conformational transition pathway in the allosteric process of human glucokinase.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.The Biochemical journal · 2002Article
- Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.The Biochemical journal · 2000Article
- Long-term maintenance of low concentrations of fructose for the study of hepatic glucose phosphorylation.The Biochemical journal · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of liver glucokinase is controlled in the short term by the concentration of its substrate glucose and by a regulatory protein, which acts as a competitive inhibitor with respect to glucose. In mammalian species, the effect of this protein is modulated by fructose 6-phosphate, which reinforces the inhibition, and by fructose 1-phosphate which antagonizes it. In the rat, the regulatory protein is found in the two tissues that express glucokinase, i.e., the liver and the pancreatic islets. Of particular interest is the fact that the regulatory protein is absent from the liver in those species that have no hepatic glucokinase. These results indicate that the two proteins form a functional unit. The regulatory protein appears in rat liver before birth, whereas glucokinase is only synthesized after 15 days of extrauterine life. The concentration of regulatory protein in the liver of the adult rat decreases by about 50% during starvation and in diabetes mellitus. Under these conditions, the difference between the concentrations of regulatory protein and glucokinase remains constant at about 0.4-0.5 nmol/g.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.