ReviewDiabetologia1994
Mechanisms modifying glucose oxidation in diabetes mellitus.
Review in Diabetologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 162 citations in OpenAlex.
- Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.Diabetologia · 1995Trial
- Cuproptosis: mechanisms and links with cancers.Molecular cancer · 2023Review
- Metabolic, structural and biochemical changes in diabetes and the development of heart failure.Diabetologia · 2022Review
- Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue.International journal of molecular sciences · 2022Article
- Unrestricted Feed Intake Induces β-Cell Death and Impairs Insulin Secretion in Broiler Breeder Hens.Animals : an open access journal from MDPI · 2020Article
- Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).Frontiers in physiology · 2020Article
- Pyruvate is an effective substitute for glutamate in regulating porcine nitrogen excretion.Journal of animal science · 2018Article
- Eulogy for the Metabolic Clinical Investigator?Diabetes · 2016Article
- Metabolic adaptations in the adipose tissue that underlie the body fat mass gain in middle-aged rats.Age (Dordrecht, Netherlands) · 2015Article
- In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.Journal of toxicology and environmental health. Part A · 2015Article
- Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets.Diabetes · 2014Article
- Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.Frontiers in endocrinology · 2013Article
- Metabolic sensing and the brain: who, what, where, and how?Endocrinology · 2011Review
- Article
- Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.American journal of physiology. Endocrinology and metabolism · 2010Article
- Influence of insulin on glucose metabolism and energy expenditure in septic patients.Critical care (London, England) · 2004Article
- Energy metabolism in the hypertrophied heart.Heart failure reviews · 2002Review
- Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts.Cardiovascular research · 2002Article
- Metabolic complications of obesity.Endocrine · 2000Review
- The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.The Biochemical journal · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Glucose Fatty Acid Cycle as formulated 30 years ago and reviewed in the Minkowski lecture in 1966 described short term effects of fatty acids (minutes) to decrease uptake, glycolysis and oxidation of glucose in heart and skeletal muscles. Such short term effects have since been extended to include inhibition of glucose uptake and glycolysis and stimulation of gluconeogenesis in liver and these effects have also been convincingly demonstrated in man in vivo. More recently a longer term effect of fatty acid metabolism to decrease glucose oxidation (hours) has been shown in heart and skeletal muscle and liver. This effect increases the specific activity of pyruvate dehydrogenase kinase, which in turn results in enhanced phosphorylation and inactivation of the pyruvate dehydrogenase complex. Activity of the pyruvate dehydrogenase complex is the major determinant of glucose oxidation rate. It seems likely that longer term effects of fatty acids on this and other aspects of glucose metabolism could be important in the development of insulin resistance in diabetes mellitus in man.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.