ArticleCalcified tissue international1994
Alternative splicing of the mouse amelogenin primary RNA transcript.
Article in Calcified tissue international, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 95 citations in OpenAlex.
- A splicing-derived microRNA from amelogenin exon4 regulates enamel formation via control of exon4 splicing and amelogenin expression.Scientific reports · 2026Article
- Antisense oligonucleotides-mediated rescue of theJournal of dental sciences · 2026Article
- Mutations Causing X-Linked Amelogenesis Imperfecta Alter miRNA Formation from Amelogenin Exon4.Journal of dental research · 2023Article
- An miRNA derived from amelogenin exon4 regulates expression of transcription factor Runx2 by directly targeting upstream activators Nfia and Prkch.The Journal of biological chemistry · 2022Article
- Minimal amelogenin domain for enamel formation.JOM (Warrendale, Pa. : 1989) · 2021Article
- Article
- Spatiotemporal Changes in Transcriptome of Odontogenic and Non-odontogenic Regions in the Dental Arch ofFrontiers in cell and developmental biology · 2021Article
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6Molecular genetics & genomic medicine · 2016Article
- Tracking endogenous amelogenin and ameloblastin in vivo.PloS one · 2014Article
- M180 amelogenin processed by MMP20 is sufficient for decussating murine enamel.Journal of dental research · 2013Article
- Alternative Splicing of the Amelogenin Gene in a Caudate Amphibian, Plethodon cinereus.PloS one · 2013Article
- Identification of a novel splicing form of amelogenin gene in a reptile, Ctenosaura similis.PloS one · 2012Article
- Article
- Rescue of the murine amelogenin null phenotype with two amelogenin transgenes.European journal of oral sciences · 2011Article
- The Amelogenin Proteins and Enamel Development in Humans and Mice.Journal of oral biosciences · 2011Article
- Bioactive nanofibers instruct cells to proliferate and differentiate during enamel regeneration.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Article
- Functions of KLK4 and MMP-20 in dental enamel formation.Biological chemistry · 2008Review
- Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1.The Biochemical journal · 2007Article
- Ultrastructural and immunohistochemical study of the influence of fluoride excess on the development of rat incisor tooth buds.Journal of applied oral science : revista FOB · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A heterogeneous mixture of amelogenins can be extracted from developing tooth enamel matrix. In an attempt to discover the extent to which alternative splicing of the amelogenin primary RNA transcript can generate unique isoforms, we have conducted a thorough search for cDNAs amplified by reverse transcription-polymerase chain reaction (RT-PCR). Over 2400 colonies were screened by colony hybridization. Seven different alternatively spliced amelogenin mRNAs were isolated. The predicted translation products of the messages are 194, 180, 156, 141, 74, 59, and 44 amino acids in length. RT-PCR amplification products not predicted by these seven amelogenin cDNAs were characterized. The intron separating exons 5 and 6 was cloned and sequenced. Using rapid amplification of cDNA ends (RACE) techniques, the 5' ends of the amelogenin mRNAs were cloned and characterized. The finding that the same exon 1 is common to all of the cloned mRNAs indicates that mouse amelogenin is transcribed from a single promoter. The mouse amelogenin transcription and translation initiation sites, the 5' untranslated leader, and the segment encoding the signal peptide were determined. The distinctly nonamelogenin-like exon 4, first observed in human amelogenin cDNAs, has also been found in mice. Antibodies were raised to synthetic exon 4-encoded polypeptides and used to immunostain Western transfers and histologic tooth sections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.