ReviewBreast cancer research and treatment1994
Tumor suppressor genes and their roles in breast cancer.
Review in Breast cancer research and treatment, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Natural products as drug candidates for breast cancer (Review).Oncology letters · 2023Review
- Growth Inhibitory Efficacy of Chinese Herbs in a Cellular Model for Triple-Negative Breast Cancer.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Growth inhibitory efficacy ofOncology letters · 2019Article
- Growth inhibitory efficacy of natural products in a model for triple negative molecular subtype of clinical breast cancer.Biomedical reports · 2017Article
- Cellular mechanisms of tumour suppression by the retinoblastoma gene.Nature reviews. Cancer · 2008Review
- Molecular pathology of tumor metastasis. I. Predictive pathology.Pathology oncology research : POR · 2001Review
- Review
- Gene therapy for carcinoma of the breast: Genetic ablation strategies.Breast cancer research : BCR · 2000Review
- Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.Oncogene · 1999Article
- Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation.Molecular and cellular biology · 1998Article
- Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.British journal of cancer · 1998Article
- Expression of molecular biomarkers in primary breast tumors implanted into a surrogate host: increased levels of cyclins correlate with tumor progression.Molecular medicine (Cambridge, Mass.) · 1997Article
- The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression.Breast cancer research and treatment · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tumor suppressor genes have been identified by the occurrence of mutations in many families with hereditary forms of cancer, exposed during development of the tumor by loss of heterozygosity. They have a number of diverse functions. For example, both the RB gene of retinoblastoma and the p53 gene, which is commonly mutated in breast and colon cancer among others, produce proteins involved in distinct steps of cell cycle control, while the nm23 product prevents metastasis. Here we review the data developed until now on the possible presence and role of mutations in these and other tumor suppressor genes in breast cancer. A more complete understanding of the tumor suppressor genes could not only provide diagnostic information, but could lead to specific gene therapy to replace suppressor functions lost in individual tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.