ArticleAntimicrobial agents and chemotherapy1993
Structure-function analysis of antimicrotubule dinitroanilines against promastigotes of the parasitic protozoan Leishmania mexicana.
Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum.International journal for parasitology. Drugs and drug resistance · 2017Article
- Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.Bioorganic & medicinal chemistry · 2016Article
- Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites.International journal for parasitology. Drugs and drug resistance · 2013Article
- Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii.Bioorganic & medicinal chemistry letters · 2010Article
- Characterization of trifluralin binding with recombinant tubulin from Trypanosoma brucei.Parasitology research · 2009Article
- Leishmania tarentolae: purification and characterization of tubulin and its suitability for antileishmanial drug screening.Experimental parasitology · 2006Article
- Synthesis and evaluation of dinitroanilines for treatment of cryptosporidiosis.Antimicrobial agents and chemotherapy · 1998Article
- Microtubule inhibitors: structure-activity analyses suggest rational models to identify potentially active compounds.Antimicrobial agents and chemotherapy · 1996Article
- Efficacy of the herbicide trifluralin against four P-glycoprotein-expressing strains of Leishmania.Antimicrobial agents and chemotherapy · 1995Article
- Structure-function analysis of antimicrotubule dinitroanilines against promastigotes of the parasitic protozoan Leishmania mexicana.Antimicrobial agents and chemotherapy · 1994Article
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5 authors at 1 institution in 1 country.
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Abstract
Although leishmaniasis is a major tropical disease, the currently available drugs are toxic and inadequate. We show that the antimicrotubule herbicide trifluralin has antileishmania activity. The present study aimed at deducing the relationship between the structure of the molecule and its antiprotozoan activity. Nine dinitroanilines, all of which were analogs of trifluralin, were compared. We found that pendimethalin was 2.5-fold more potent than trifluralin, and the higher efficacy may be correlated with molecular structural features that increase the accessibility to one nitro group. This association was further supported by molecular modeling. Moreover, trifluralin samples from two sources differed in their activities by more than threefold, and gas column chromatography showed that impurities were present in the more potent sample.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.