ArticleThe Biochemical journal1994
Purification and characterization of thyroid transcription factor 2.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review.Biological trace element research · 2021Pooled it
- Effects of essential metals (iron, zinc, and copper) on thyroid diseases - a narrative review.Frontiers in medicine · 2026Review
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- The interplay of oxidative stress and immune dysfunction in Hashimoto's thyroiditis and polycystic ovary syndrome: a comprehensive review.Frontiers in immunology · 2023Review
- The protective role of nutritional antioxidants against oxidative stress in thyroid disorders.Frontiers in endocrinology · 2022Review
- The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice.Nutrients · 2021Article
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross-Sectional Study.International journal of preventive medicine · 2021Article
- Review
- Thyroid Hormone Indices in Computer Workers with Emphasis on the Role of Zinc Supplementation.Open access Macedonian journal of medical sciences · 2016Article
- Gene expression of thyroid-specific transcription factors may help diagnose thyroid lesions but are not determinants of tumor progression.Journal of endocrinological investigation · 2016Article
- A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression.Thyroid : official journal of the American Thyroid Association · 2014Article
- Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry.Thyroid : official journal of the American Thyroid Association · 2013Article
- Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis.Human genetics · 2007Article
- A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer.The Biochemical journal · 1997Article
- Metal- and DNA-binding properties and mutational analysis of the transcription activating factor, B, of coliphage 186: a prokaryotic C4 zinc-finger protein.Protein science : a publication of the Protein Society · 1997Article
- Synergistic transcriptional activation of the thyrotropin receptor promoter by cyclic AMP-responsive-element-binding protein and thyroid transcription factor 1.The Biochemical journal · 1995Article
- Diagnostic utility of DREAM gene mRNA levels in thyroid tumours.Archives of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid transcription factor 2 binds to the promoters of both thyroglobulin and thyroperoxidase genes, two markers of thyroid tissue differentiation, and its binding modulates the activity of both promoters. In this paper we describe the purification of thyroid transcription factor 2 essentially to homogeneity and demonstrate that it is a thyroid-specific DNA-binding protein. Furthermore, we provide a biochemical characterization suggesting that thyroid transcription factor 2 binds to DNA as a dimer and that it is a zinc-finger DNA-binding protein regulated in vitro by the redox state.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.