ArticleProceedings of the National Academy of Sciences of the United States of America1995
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 170 citations in OpenAlex.
- Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1.Nucleic acids research · 2026Article
- Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex.Molecular biology of the cell · 2015Article
- Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport.Molecular biology of the cell · 2014Article
- Blm10 facilitates nuclear import of proteasome core particles.The EMBO journal · 2013Article
- Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.PloS one · 2012Article
- The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development.Genetics · 2011Article
- Degradation of Saccharomyces cerevisiae transcription factor Gcn4 requires a C-terminal nuclear localization signal in the cyclin Pcl5.Eukaryotic cell · 2009Article
- The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast.The Journal of cell biology · 2009Article
- Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export.The Journal of biological chemistry · 2008Article
- Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast.Molecular and cellular biology · 2008Article
- Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality.Molecular biology of the cell · 2007Article
- Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.Molecular and cellular biology · 2006Article
- Identification and characterization of the Arabidopsis orthologs of nuclear transport factor 2, the nuclear import factor of ran.Plant physiology · 2006Article
- Nuclear export of hnRNP Hrp1p and nuclear export of hnRNP Npl3p are linked and influenced by the methylation state of Npl3p.Molecular and cellular biology · 2004Article
- Differential regulation of Tec1 by Fus3 and Kss1 confers signaling specificity in yeast development.Current genetics · 2004Article
- A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly.Eukaryotic cell · 2004Article
- Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p.The Journal of biological chemistry · 2001Article
- Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development.The EMBO journal · 2000Article
- Hydrogen peroxide inhibition of nuclear protein import is mediated by the mitogen-activated protein kinase, ERK2.The Journal of cell biology · 2000Article
- Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.Journal of virology · 1999Article
18 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
Ran/TC4, a Ras-like GTP-binding protein, and its nucleotide exchanger, RCC1, have been implicated in control of protein movement into the nucleus and cytoplasmic accumulation of mRNA. Saccharomyces cerevisiae contains two homologues of the mammalian Ran/TC4, encoded by the GSP1 and GSP2 genes. We have constructed yeast strains that overproduce either wild-type Gsp1 or a form of Gsp1 with glycine-21 converted to valine (Gsp1-G21V), which we show stabilizes the GTP-bound form. Cells producing Gsp1-G21V have defects in localization of nuclear proteins; nuclear proteins accumulate in the cytoplasm following galactose induction of Gsp1-G21V. Similarly, cells producing Gsp1-G21V retain poly(A)+ RNA in their nuclei. These findings suggest that hydrolysis of GTP by Ran/TC4 is necessary for proper import of proteins into the nucleus and appearance of poly(A)+ RNA in the cytoplasm.
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