ArticleProceedings of the National Academy of Sciences of the United States of America1995
Structure, characterization, and expression of the rat oxytocin receptor gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 190 citations in OpenAlex.
- Stress and parental behaviors.Neuroscience research · 2025Review
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.Pediatric research · 2025Review
- Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders.Medicina (Kaunas, Lithuania) · 2022Review
- The Biology of Vasopressin.Biomedicines · 2021Review
- Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats.British journal of pharmacology · 2014Article
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Oxytocin: the great facilitator of life.Progress in neurobiology · 2009Review
- Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells.The Journal of physiology · 2006Article
- Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris).The Biochemical journal · 2005Article
- Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Oxytocin and its receptors are synthesized in the rat vasculature.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells.British journal of pharmacology · 2000Article
- Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster.Molecular medicine (Cambridge, Mass.) · 1996Article
- Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family.Cellular and molecular neurobiology · 1995Review
- Extrapituitary expression of the rat V1b vasopressin receptor gene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Constitutive and ligand-induced nuclear localization of oxytocin receptor.Journal of cellular and molecular medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multiple hormonal and neurotransmitter functions of the nonapeptide oxytocin are mediated by specific oxytocin receptors (OTRs). In most target tissues, the number of OTRs is strongly regulated. Specifically, in the uterus, a dramatic OTR upregulation precedes the onset of parturition. To study the molecular mechanisms underlying OTR regulation, we have isolated and characterized recombinant bacteriophage lambda EMBL3 genomic clones containing the rat OTR gene, using sequence information derived from a human myometrial OTR cDNA. The rat OTR gene spans > 20 kb and contains three exons. A 97-bp intron is in the 5' untranslated region and a > 12-kb intron interrupts the coding region between transmembrane domains 6 and 7. The promoter region lacks an apparent TATA or CCAAT box but contains multiple putative interleukin-response elements [six NF-IL6 (C/EBP beta) and four APRF (STAT3) binding motifs], supporting the notion that interleukins may mediate labor induction via transcriptional activation of the OTR gene. The predicted amino acid sequence is 93% identical to the human OTR sequence but only 48% and 38% identical to the rat V1 and V2 vasopressin receptor sequences, respectively. At parturition, the OTR gene is highly expressed in the rat uterus and gives rise to at least three transcripts (2.9, 4.8, and 6.7 kb) which differ in the length of their 3' untranslated regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.