ArticleProceedings of the National Academy of Sciences of the United States of America1995
Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.The Journal of experimental medicine · 2018Article
- Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response.Journal of molecular endocrinology · 2016Article
- Progress in detecting cell-surface protein receptors: the erythropoietin receptor example.Annals of hematology · 2014Review
- Article
- Erythropoiesis stimulating agents: approaches to modulate activity.Biologics : targets & therapy · 2013Article
- Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.The Journal of biological chemistry · 2012Article
- The effect of erythropoietin on normal and neoplastic cells.Biologics : targets & therapy · 2012Article
- Survival and proliferative roles of erythropoietin beyond the erythroid lineage.Expert reviews in molecular medicine · 2008Review
- Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells.British journal of cancer · 2008Article
- An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A model of the ternary complex of interleukin-10 with its soluble receptors.BMC structural biology · 2005Article
- Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling.The Biochemical journal · 2004Article
- Proteolysis of type I inositol 1,4,5-trisphosphate receptor in WB rat liver cells.The Biochemical journal · 2003Article
- Overview of protein expression by mammalian cells.Current protocols in protein science · 2001Article
- Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo.Oncogene · 2000Article
- Phosphorylation of erythropoietin receptors in the endoplasmic reticulum by pervanadate-mediated inhibition of tyrosine phosphatases.The Biochemical journal · 1997Article
- Formation of native hepatitis C virus glycoprotein complexes.Journal of virology · 1997Article
- Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In both transfected and normal hematopoietic cells, the majority of newly made erythropoietin receptor (EPO-R) subunits are retained in the endoplasmic reticulum (ER), destined for degradation. Only a small fraction exit the ER and are competent to bind EPO, suggesting that the EPO-R folds inefficiently. The EPO-R contains a 5-amino acid motif, WSXWS, in the extracellular domain that is conserved among members of the cytokine receptor family. We describe a mutant EPO-R with a change in the middle residue of this motif, A234E, that is transported from the ER more efficiently than the wild-type (wt) receptor and is expressed in elevated numbers at the cell surface. This mutant polypeptide is processed more efficiently in the ER than its wt counterpart, suggesting that it folds better than the wt EPO-R. Inefficient folding and processing of the wt EPO-R in the ER may be one mechanism for controlling the number of plasma membrane receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.