ArticlePharmaceutical research1994
Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake.
Article in Pharmaceutical research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles.Cancer nanotechnology · 2017Review
- A Polyethylenimine-Containing and Transferrin-Conjugated Lipid Nanoparticle System for Antisense Oligonucleotide Delivery to AML.BioMed research international · 2016Article
- Mannosylated chitosan nanoparticles for delivery of antisense oligonucleotides for macrophage targeting.BioMed research international · 2014Article
- Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme.Investigational new drugs · 2013Article
- Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA.British journal of pharmacology · 2009Review
- Signaling pathways in spermatogonial stem cells and their disruption by toxicants.Birth defects research. Part C, Embryo today : reviews · 2009Review
- Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics.Gene regulation and systems biology · 2008Article
- Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging.Journal of the American Chemical Society · 2008Article
- Nanotechnology: intelligent design to treat complex disease.Pharmaceutical research · 2006Review
- In vitro cytotoxicity of nanoparticles in mammalian germline stem cells.Toxicological sciences : an official journal of the Society of Toxicology · 2005Article
- New technologies for drug delivery across the blood brain barrier.Current pharmaceutical design · 2004Review
- Innovations in oligonucleotide drug delivery.Journal of pharmaceutical sciences · 2003Review
- The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides.Biomaterials · 2002Review
- Delivery of oligonucleotides into mammalian cells by anionic peptides: comparison between monomeric and dimeric peptides.The Biochemical journal · 2001Article
- Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells.Gene therapy · 2000Article
- Polyisobutylcyanoacrylate nanocapsules containing an aqueous core as a novel colloidal carrier for the delivery of oligonucleotides.Pharmaceutical research · 2000Article
- Submicron cationic emulsions as a new delivery system for oligonucleotides.Pharmaceutical research · 1999Article
- Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice.Pharmaceutical research · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligonucleotides can be adsorbed on polyisohexylcyanoacrylate nanoparticles in the presence of hydrophobic quarternary ammonium salts. Oligonucleotides bound to nanoparticles are protected from nuclease attack both in buffer and in cell culture media. Cellular uptake of oligonucleotides is increased when they are adsorbed onto nanoparticles as a result of the capture of nanoparticles by an endocytic phagocytic pathway. Intracellular stability towards nucleolytic degradation is increased in the presence of nanoparticles. These results show that nanoparticles can be considered as convenient carriers for the protection and delivery of oligonucleotides to cells.
Indexed as
Identifiers
7816773What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.