ArticlePflugers Archiv : European journal of physiology1994
Volume-activated Cl- currents in different mammalian non-excitable cell types.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 98 citations in OpenAlex.
- Effect of VSOR/VRAC blocker tamoxifen on contractile activity of primary neonatal cardiomyocytes and isolated perfused heart.BMC research notes · 2026Article
- Article
- VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1.International journal of molecular sciences · 2022Article
- 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid inhibits angiogenesisFrontiers in cardiovascular medicine · 2022Article
- Ectonucleotidases in Acute and Chronic Inflammation.Frontiers in pharmacology · 2020Review
- The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.Scientific reports · 2019Article
- The Volume-Regulated Anion Channel in Glioblastoma.Cancers · 2019Review
- ATP Release Channels.International journal of molecular sciences · 2018Review
- VRACs and other ion channels and transporters in the regulation of cell volume and beyond.Nature reviews. Molecular cell biology · 2016Review
- VRAC: molecular identification as LRRC8 heteromers with differential functions.Pflugers Archiv : European journal of physiology · 2016Review
- Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm.Pathophysiology : the official journal of the International Society for Pathophysiology · 2007Article
- Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.Neurochemical research · 2007Article
- Pitfalls when examining gap junction hemichannels: interference from volume-regulated anion channels.Pflugers Archiv : European journal of physiology · 2006Article
- Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes.The Journal of physiology · 2006Article
- Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.Neurochemical research · 2004Review
- Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes.The Journal of general physiology · 2003Article
- Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine.British journal of pharmacology · 2001Article
- Pharmacological characterization of volume-sensitive, taurine permeable anion channels in rat supraoptic glial cells.British journal of pharmacology · 2000Article
- Tamoxifen and ATP synergistically activate Cl- release by cultured bovine pigmented ciliary epithelial cells.The Journal of physiology · 2000Article
- Stretch-activated and background non-selective cation channels in rat atrial myocytes.The Journal of physiology · 2000Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence and properties of volume-activated Cl- currents were studied in 15 different cell types (endothelium: human umbilical vein, human aorta, bovine pulmonary artery; fibroblasts: Swiss 3T3, L, C3H 10T1/2 and COS-1; epithelium: KB3, HeLa and A6; blood cells: RBL-2H3 and Jurkat; endothelioma cells derived from both subcutaneous and thymic hemangiomas; skin: IGR1 melanoma). Volume-activated Cl- currents with common characteristics, i.e. small conductance, outward rectification, higher permeability for iodide than for chloride and sensitivity to block by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) could be elicited in all cells. The block of this current by tamoxifen and dideoxyforskolin is different for the various cell types, as well as the time course and the amplitude of the responses induced by repetitive applications of hypotonicity. Volume-activated Cl- channels with similar biophysical properties are therefore wide-spread among mammalian cells. This may reflect either a single Cl- channel that is ubiquitously expressed or a family of functionally related Cl- channels with cell specific expression patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.