ReviewMolecular and cellular biochemistry1994
Calreticulin: not just another calcium-binding protein.
Review in Molecular and cellular biochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 134 citations in OpenAlex.
- A calreticulin-linked HPV-16 E7 minigene DNA vaccine elicits strong E7-specific CD8+ T-cell immunity and durable antitumor effects in a preclinical model.Scientific reports · 2026Article
- Luminal transport through intact endoplasmic reticulum limits the magnitude of localized CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy.Cancers · 2021Article
- Most calbindin-immunoreactive neurons, but few calretinin-immunoreactive neurons, express the m1 acetylcholine receptor in the middle temporal visual area of the macaque monkey.Brain and behavior · 2018Article
- Dissecting physical structure of calreticulin, an intrinsically disordered CaJournal of biomolecular structure & dynamics · 2018Article
- Adaptive changes of telocytes in the urinary bladder of patients affected by neurogenic detrusor overactivity.Journal of cellular and molecular medicine · 2018Article
- Heterologous expression of rice calnexin (OsCNX) confers drought tolerance in Nicotiana tabacum.Molecular biology reports · 2013Article
- Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.PloS one · 2013Article
- Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion.The Journal of biological chemistry · 2012Article
- Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection.PloS one · 2012Article
- Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.Frontiers in immunology · 2012Article
- Calreticulin is a thermostable protein with distinct structural responses to different divalent cation environments.The Journal of biological chemistry · 2011Article
- Construction and characterization of calreticulin-HBsAg fusion gene recombinant adenovirus expression vector.World journal of gastroenterology · 2010Article
- Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines.Acta naturae · 2010Article
- The differential expression of aqueous soluble proteins in breast normal and cancerous tissues in relation to stage and grade of patients.Journal of biomedicine & biotechnology · 2010Article
- Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts.Cancer immunology, immunotherapy : CII · 2009Article
- The role of saliva in tick feeding.Frontiers in bioscience (Landmark edition) · 2009Review
- Enhancement of DNA vaccine potency through coadministration of CIITA DNA with DNA vaccines via gene gun.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Article
- Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice.Cancer immunology, immunotherapy : CII · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we review some of the rapidly expanding information about calreticulin, a Ca(2+)-binding/storage protein of the endoplasmic reticulum. The emphasis is placed on the structure and function of calreticulin. We believe that calreticulin is a multifunctional Ca(2+)-binding protein and that distinct functional properties of the protein may be localized to each of the three structural domains of calreticulin. Most evidence indicates that calreticulin is a resident endoplasmic reticulum protein. However, it can also be found outside of the endoplasmic reticulum compartment, i.e. in the nuclear envelope, in the nucleus, in the cytotoxic granules in T-lymphocytes and in acrosomal vesicles of sperm cells. The evidence reviewed here clearly suggests that calreticulin has other functions in addition to its role as a Ca2+ storage protein in the endoplasmic reticulum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.