ArticleJournal of virology1995
Eighteen baculovirus genes, including lef-11, p35, 39K, and p47, support late gene expression.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 135 citations in OpenAlex.
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- Construction and characterization of a synthetic Baculovirus-inducible 39K promoter.Journal of biological engineering · 2018Article
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- The transcriptome of the baculovirus Autographa californica multiple nucleopolyhedrovirus in Trichoplusia ni cells.Journal of virology · 2013Article
- Functional analysis of Spodoptera frugiperda nucleopolyhedrovirus late expression factors in Sf9 cells.Virus genes · 2013Article
- The screening and functional study of proteins binding with the BmNPV polyhedrin promoter.Virology journal · 2012Article
- Proteomics of the Autographa californica nucleopolyhedrovirus budded virions.Journal of virology · 2010Article
- Promoter analysis of Bombyx mori nucleopolyhedrovirus ubiquitin gene.Journal of microbiology (Seoul, Korea) · 2008Article
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- A baculovirus alkaline nuclease knockout construct produces fragmented DNA and aberrant capsids.Virology · 2007Article
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- Characterization of the role of very late expression factor 1 in baculovirus capsid structure and DNA processing.Journal of virology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report the identification of four additional genes of the Autographa californica nuclear polyhedrosis virus involved in expression from a late baculovirus promoter in transient expression assays. Three of these genes, p35, 39K, and p47, have been previously described. The role of the p35 gene product in late gene expression may be related to its ability to block apoptosis, since two other baculovirus genes also known to block apoptosis, Cp-iap and Op-iap, were able to functionally replace p35 in the transient expression assay. The requirement for p47 in this assay confirms its role in late gene expression, a role previously established by characterization of a temperature-sensitive mutant of p47, while the requirement for 39K may be related to its known association with the virogenic stroma. The fourth gene identified as a late expression factor gene, lef-11, was located immediately upstream of 39K and is predicted to encode a 13-kDa polypeptide. When plasmids containing these 4 genes were cotransfected with plasmids containing the 14 genes previously identified as late gene expression factors, the level of expression from the late capsid promoter was similar to that observed for a library of clones representing the entire viral genome. The genes provided by these 18 plasmids thus represent the viral genes necessary and sufficient to support expression from a late viral promoter in this transient expression assay.
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