ArticleJournal of virology1995
Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 118 citations in OpenAlex.
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- Vaccination strategies to combat novel corona virus SARS-CoV-2.Life sciences · 2020Review
- Activated GL7Brain, behavior, and immunity · 2017Article
- T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV.Antiviral research · 2017Review
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain.Neuropathology : official journal of the Japanese Society of Neuropathology · 2010Article
- A mechanism of virus-induced demyelination.Interdisciplinary perspectives on infectious diseases · 2010Article
- Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infection.Journal of virology · 2009Article
- SARS vaccines: where are we?Expert review of vaccines · 2009Review
- Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.Journal of virology · 2008Article
- Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes.Journal of virology · 2008Article
- Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus.Brain pathology (Zurich, Switzerland) · 2008Article
- Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system.Journal of virology · 2007Article
- Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients.Virology · 2006Article
- Both spike and background genes contribute to murine coronavirus neurovirulence.Journal of virology · 2006Article
- Preferential infection of mature dendritic cells by mouse hepatitis virus strain JHM.Journal of virology · 2006Article
- Preferential infection of mature dendritic cells by the JHM strain of mouse hepatitis virus.Advances in experimental medicine and biology · 2006Article
- Receptor-independent spread of a highly neurotropic murine coronavirus JHMV strain from initially infected microglial cells in mixed neural cultures.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acute infection of the central nervous system by the neurotropic JHM strain of mouse hepatitis virus (JHMV) induces nucleocapsid protein specific cytotoxic T lymphocytes (CTL) not found in the periphery (S. Stohlman, S. Kyuwa, J. Polo, D. Brady, M. Lai, and C. Bergmann, J. Virol. 67:7050-7059, 1993). Peripheral induction of CTL specific for the nucleocapsid protein of JHMV by vaccination with recombinant vaccinia viruses was unable to provide significant protection to a subsequent lethal virus challenge. By contrast, the transfer of nucleoprotein-specific CTL protected mice from a subsequent lethal challenge by reducing virus replication within the central nervous system, demonstrating the importance of the CTL response to this epitope in JHMV infection. Transfer of these CTL directly into the central nervous system was at least 10-fold more effective than peripheral transfer. Histological analysis indicated that the CTL reduced virus replication in ependymal cells, astrocytes, and microglia. Although the CTL were relatively ineffective at reducing virus replication in oligodendroglia, survivors showed minimal evidence of virus persistence within the central nervous system and no evidence of chronic ongoing demyelination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.