ArticleJournal of clinical immunology1994
Evidence for an abnormal profile of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma-IFN) in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis.
Article in Journal of clinical immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.The Journal of allergy and clinical immunology · 2014Trial
- Eosinophilic Duodenitis Presenting As Severe Iron Deficiency Anemia: A Rare Presentation.Cureus · 2024Article
- Eosinophilic gastrointestinal disorders: a narrative review on clinical perspectives and research gaps in the Asian context.Translational gastroenterology and hepatology · 2024Review
- Balancing immune responses: regulatory cells in eosinophilic gastrointestinal disorders.Frontiers in immunology · 2024Review
- Article
- Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders.Immunology · 2019Article
- Evaluation of gene expression change in eosinophilic gastroenteritis.Gastroenterology and hepatology from bed to bench · 2019Article
- Eosinophilic gastroenteritis: diagnosis and clinical perspectives.Clinical and experimental gastroenterology · 2019Review
- Intestinal overexpression of interleukin (IL)-15 promotes tissue eosinophilia and goblet cell hyperplasia.Immunology and cell biology · 2018Article
- Food-Induced Acute Pancreatitis.Digestive diseases and sciences · 2017Review
- Eosinophilic gastroenteritis: Approach to diagnosis and management.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- Eosinophilic Esophagitis and Gastroenteritis.Current allergy and asthma reports · 2015Review
- Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders.Journal of genetic syndromes & gene therapy · 2015Article
- Eosinophilic gastroenteritis and related eosinophilic disorders.Gastroenterology clinics of North America · 2014Article
- Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract.The Journal of allergy and clinical immunology · 2010Review
- Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses.The Journal of allergy and clinical immunology · 2009Article
- Clinical problem-solving. The writing on the wall.The New England journal of medicine · 2009Article
- Chemotactic factors associated with eosinophilic gastrointestinal diseases.Immunology and allergy clinics of North America · 2009Review
- Eosinophilic gastroenteritis: a review.Journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic eosinophilic gastroenteritis is characterized by elevated total IgE, specific IgE to food antigens, and eosinophilia of tissue and blood. Because the lymphokines IL-4, IL-5, and gamma-interferon, regulate IgE synthesis, and eosinophilopoiesis in vitro, we examined whether there is an imbalance in their production in allergic eosinophilic gastroenteritis. To explore this hypothesis, three adult patients with allergic eosinophilic gastroenteritis were studied. Flow cytometric studies of peripheral blood mononuclear cells from these patients did not reveal evidence of T cell activation or disturbance of T cell numbers or subsets. T cells were capable of normal mitogenic activation in vitro. IL-4 and IL-5 production were markedly elevated with mitogenic stimulation. Most IL-4 and IL-5 production was by CD4+ T cells. Synthesis of IL-5 by CD4+ T lymphocytes in three patients and CD8+ T lymphocytes in two patients occurred in the absence of mitogen. Mitogen-stimulated GM-CSF and gamma-interferon synthesis by CD4+ T cells was normal. Lymphokine mRNA in total cellular RNA derived from endoscopic biopsies was examined by reverse transcription/polymerase chain reaction. Mucosal biopsies from control subjects and most biopsies from allergic eosinophilic gastroenteritis patients contained less than 10(-8) micrograms IL-5 mRNA/1 microgram total cellular mRNA. gamma-Interferon mRNA was not detected by reverse transcription/polymerase chain reaction in biopsies from patients with allergic eosinophilic gastroenteritis but was present in controls. These lymphokine abnormalities are consistent with the elevated IgE and eosinophilia seen in allergic eosinophilic gastroenteritis and suggest that strategies targeting T lymphocytes may be efficacious in treatment of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.