ArticleExperimental brain research1994
Phasic stimulation of the locus coeruleus: effects on activity in the lateral geniculate nucleus.
Article in Experimental brain research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales.PLoS biology · 2024Article
- Age-related changes in pupil dynamics and task modulation across the healthy lifespan.Frontiers in neuroscience · 2024Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Probing the structure and function of locus coeruleus projections to CNS motor centers.Frontiers in neural circuits · 2022Article
- Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review.Neuroscience and biobehavioral reviews · 2019Review
- Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer's Disease.Neurotoxicity research · 2016Review
- Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Effects of intracerebroventricular corticotropin releasing factor on sensory-evoked responses in the rat visual thalamus.Brain research · 2014Article
- The beneficial effects of meditation: contribution of the anterior cingulate and locus coeruleus.Frontiers in psychology · 2013Article
- Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat.European journal of pharmacology · 2012Article
- Phasic and tonic patterns of locus coeruleus output differentially modulate sensory network function in the awake rat.Journal of neurophysiology · 2011Article
- Locus ceruleus regulates sensory encoding by neurons and networks in waking animals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The effects of tonic locus ceruleus output on sensory-evoked responses of ventral posterior medial thalamic and barrel field cortical neurons in the awake rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems.Experimental brain research · 2003Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons in the locus coeruleus (LC) encode information related to behavioral state in a tonic pattern of firing and information related to the occurrence of a sensory stimulus in a phasic pattern of firing. The effects of phasic stimulation of the LC (6 pulses at 30 Hz), designed to approximate its physiological activation by sensory stimuli, were studied in the lateral geniculate nucleus (LGN) of anesthetized rats. Phasic stimulation of the LC significantly increased neuronal firing in the LGN with a mean latency 320 ms from onset of stimulation. Receiver operating characteristic analyses on a trial-by-trial basis showed that phasic LC stimulation can result in a highly discriminable signal in the LGN. This increased neuronal firing rate in the LGN was specific for the site of stimulation and was reduced by the norepinephrine synthesis inhibitor alpha-methyl-p-tyrosine and by intravenous WB-4101 (alpha 1-receptor antagonist). Neurons in the LGN have a single-spike firing mode when sensory information is faithfully relayed from retina to cortex and a burst-firing mode when the transfer of this information is degraded. Phasic LC stimulation reduced burst firing (2-5 ms interspike intervals, ISIs) at low frequencies (< or = 4 Hz) in the LGN, and for some neurons there was an absolute decrease in burst-like ISIs after LC stimulation, despite an increase in mean firing rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.