ArticleThe EMBO journal1994
A surrogate 15 kDa JC kappa protein is expressed in combination with mu heavy chain by human B cell precursors.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101.Frontiers in immunology · 2018Article
- The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.PloS one · 2015Article
- Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of Vertebrates.Results and problems in cell differentiation · 2015Review
- Immunoglobulin light chains in medaka (Oryzias latipes).Immunogenetics · 2013Article
- A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.Immunogenetics · 2012Article
- Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival.The EMBO journal · 1996Article
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Authors and funding
8 authors.
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Abstract
A novel kappa protein, encoded by a germline JC kappa transcript, is expressed by normal and leukemic human B cell precursors. The transcript displays an open reading frame initiated by a non-AUG codon, and predicts a 15 kDa molecule which could be readily confirmed by in vitro translation. Cellular expression was demonstrated by immunofluorescence, precipitation and Western blotting. Furthermore, 2-D gel electrophoresis revealed that germline JC kappa can covalently associate with mu heavy chain at the surface of pre-B cells. We therefore propose that during B cell lymphopoiesis, two alternative pathways could be operative in which mu heavy chain can either associate with lambda 5 or germ-line JC kappa.
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Registered trials
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