ArticleClinical and experimental immunology1995
In vitro and in vivo T cell responses in mice during bronchopulmonary infection with mucoid Pseudomonas aeruginosa.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Article
- X-ray Irradiated Vaccine Confers protection against Pneumonia caused by Pseudomonas aeruginosa.Scientific reports · 2016Article
- The role of CD1d-restricted NKT cells in the clearance of Pseudomonas aeruginosa from the lung is dependent on the host genetic background.Infection and immunity · 2015Article
- Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens.Frontiers in microbiology · 2015Review
- Modular microfluidic system as a model of cystic fibrosis airways.Biomicrofluidics · 2012Article
- Animal welfare in studies on murine tuberculosis: assessing progress over a 12-year period and the need for further improvement.PloS one · 2012Review
- Recent developments for Pseudomonas vaccines.Human vaccines · 2011Review
- Article
- Acyl homoserine lactones from culture supernatants of Pseudomonas aeruginosa accelerate host immunomodulation.PloS one · 2011Article
- IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Protective immunity to pseudomonas aeruginosa induced with a capsid-modified adenovirus expressing P. aeruginosa OprF.Journal of virology · 2007Article
- Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.The Journal of clinical investigation · 2005Article
- The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy.Infection and immunity · 2005Article
- Differential immune modulatory activity of Pseudomonas aeruginosa quorum-sensing signal molecules.Infection and immunity · 2004Article
- Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge.Clinical and experimental immunology · 2004Article
- Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant.Infection and immunity · 2003Article
- Gammadelta T lymphocytes from cystic fibrosis patients and healthy donors are high TNF-alpha and IFN-gamma-producers in response to Pseudomonas aeruginosa.Respiratory research · 2003Article
- Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response.Clinical and experimental immunology · 2002Article
- Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro and in vivo T cell responses were determined during the course of bronchopulmonary infection with mucoid Pseudomonas aeruginosa. T cell responses were compared in two inbred mouse strains, namely BALB/c mice, which are resistant to the establishment of chronic bronchopulmonary Ps. aeruginosa infection, and C57Bl/6 mice, which have high numbers of bacteria in the lungs through 14 days post-infection. Unseparated lung cells and lung T cells from BALB/c mice exhibited significantly higher in vitro proliferative responses to both heat-killed Ps. aeruginosa and concanavalin A (Con A) than cells from C57Bl/6 mice through 20 days post-intratracheal infection with 10(4) colony-forming units (CFU) Ps. aeruginosa. Proliferation of unseparated lung cells but not lung T cells from BALB/c mice infected 6 days previously with 10(5) CFU Ps. aeruginosa was suppressed in response to Con A; these cells were unresponsive to specific antigen. Suppression of lymphocyte proliferation in the lungs of C57Bl/6 mice infected with 10(4) CFU Ps. aeruginosa and in BALB/c mice infected with 10(5) CFU was found to be mediated by adherent lung cells via the production of nitric oxide and prostaglandins. Determination of in vivo T cell-mediated responses in infected mice demonstrated that resistant BALB/c mice had high DTH and low Pseudomonas-specific antibody responses, while C57Bl/6 mice had low DTH and high antibody levels, in particular, IgG2b and IgM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.