ArticleBritish journal of pharmacology1994
Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors.
Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Dual mechanisms of angiotensin-induced activation of mouse sympathetic neurones.The Journal of physiology · 2006Article
- Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes.The Journal of physiology · 2005Article
- Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Influence of phorbol esters on contractile force, action potential and calcium current of isolated guinea-pig heart tissues.Basic research in cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of 1-oleoyl-2-acetyl-sn-glycerol (OAG), phorbol 12-myristate 13-acetate (PMA), 4-alpha-phorbol and muscarine on B-neurones from bull-frog sympathetic ganglion were studied by means of whole-cell patch-clamp recording. With the exception of 4-alpha-phorbol, all of these agonists reduced the steady-state outward current recorded at -30 mV as a result of suppression of a voltage-dependent, non-inactivating K(+)-current, the M-current, (IM). 2. Of the cells tested, 34% displayed bona fide responses to OAG (20 microM). The chance of recording a response was not decreased when the protein kinase inhibitor, 1-(5-isoquinolinylsulphonyl)-2-methyl-piperazine (H-7; 50 or 75 microM) was included simultaneously in the extracellular solution and in the pipette solution. 3. The presence of 50 microM H-7 on both sides of the membrane or 500 nM staurosporine in the pipette solution did not prevent responses to brief (1-2 min) or prolonged (> 20 min) applications of PMA. 4. Brief (1-2 min) extracellular application of H-7 (300 microM) suppressed IM by about 29%. 5. The most likely explanation of these data is that PMA and OAG modulate IM via a mechanism that is independent of protein kinase C (PKC). The availability of such a mechanism poses new questions as to the mechanism of muscarine-induced IM suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.