ArticleMolecular biology of the cell1994
Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity.
Article in Molecular biology of the cell, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Organelle scaling over a 100-fold cell size range.bioRxiv : the preprint server for biology · 2026Article
- Functional redundancy and formin-isoform independent localization of tropomyosin paralogs in Saccharomyces cerevisiae.PLoS genetics · 2025Article
- Myosin A and F-Actin play a critical role in mitochondrial dynamics and inheritance in Toxoplasma gondii.PLoS pathogens · 2024Article
- Myosin A and F-Actin play a critical role in mitochondrial dynamics and inheritance inbioRxiv : the preprint server for biology · 2024Article
- Mitochondria-actin cytoskeleton crosstalk in cell migration.Journal of cellular physiology · 2022Review
- Mitochondrial respiration is sensitive to cytoarchitectural breakdown.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae.Molecular biology of the cell · 2016Article
- Mitochondrial dynamics and inheritance during cell division, development and disease.Nature reviews. Molecular cell biology · 2014Review
- Mitochondrial motility and vascular smooth muscle proliferation.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae.The Journal of cell biology · 2008Article
- Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast.The Journal of cell biology · 2007Article
- Roles of type II myosin and a tropomyosin isoform in retrograde actin flow in budding yeast.The Journal of cell biology · 2006Article
- Possible association of actin filaments with chloroplasts of spinach mesophyll cells in vivo and in vitro.Protoplasma · 2006Article
- A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast.Molecular biology of the cell · 2005Article
- Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.The Journal of cell biology · 2005Article
- Live cell imaging of the assembly, disassembly, and actin cable-dependent movement of endosomes and actin patches in the budding yeast, Saccharomyces cerevisiae.The Journal of cell biology · 2004Article
- Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway.The Journal of cell biology · 2004Article
- Mitochondrial dynamics.The New phytologist · 2003Review
- A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery.Molecular biology of the cell · 2003Article
- Mechanisms of mitochondria-neurofilament interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sedimentation assays were used to demonstrate and characterize binding of isolated yeast mitochondria to phalloidin-stabilized yeast F-actin. These actin-mitochondrial interactions are ATP sensitive, saturable, reversible, and do not depend upon mitochondrial membrane potential. Protease digestion of mitochondrial outer membrane proteins or saturation of myosin-binding sites on F-actin with the S1 subfragment of skeletal myosin block binding. These observations indicate that a protein (or proteins) on the mitochondrial surface mediates ATP-sensitive, reversible binding of mitochondria to the lateral surface of microfilaments. Actin copurifies with mitochondria during subcellular fractionation and is released from the organelle upon treatment with ATP. Thus, actin-mitochondrial interactions resembling those observed in vitro may also exist in intact yeast cells. Finally, a yeast mutant bearing a temperature-sensitive mutation in the actin-encoding ACT1 gene (act1-3) displays temperature-dependent defects in transfer of mitochondria from mother cells to newly developed buds during yeast cell mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.