ArticleProceedings of the National Academy of Sciences of the United States of America1994
Altered inflammatory responses in leukotriene-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 188 citations in OpenAlex.
- Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues.Mucosal immunology · 2025Article
- miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.Oncotarget · 2018Article
- LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats.American journal of translational research · 2018Article
- Leptin MediatesFrontiers in immunology · 2018Article
- Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.Science immunology · 2017Article
- Cytochrome P450 and Lipoxygenase Metabolites on Renal Function.Comprehensive Physiology · 2015Review
- The role of lipoxygenases in pathophysiology; new insights and future perspectives.Redox biology · 2015Review
- Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.Nature communications · 2015Article
- Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.Human molecular genetics · 2014Article
- Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.Biochimica et biophysica acta · 2014Article
- Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.Neurobiology of aging · 2014Article
- Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.Molecular psychiatry · 2014Article
- Effect of ascophyllan from brown algae Padina tetrastromatica on inflammation and oxidative stress in carrageenan-induced rats.Inflammation · 2013Article
- Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice.Aging cell · 2013Article
- 5-Lipoxygenase facilitates healing after myocardial infarction.Basic research in cardiology · 2013Article
- Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Evaluation of Artemisia amygdalina D. for Anti-Inflammatory and Immunomodulatory Potential.ISRN inflammation · 2013Article
- The complement system in ischemia-reperfusion injuries.Immunobiology · 2012Review
- ONZIN deficiency attenuates contact hypersensitivity responses in mice.Immunology and cell biology · 2012Article
- Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.Current medicinal chemistry · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.