ArticleProceedings of the National Academy of Sciences of the United States of America1994
Molecular evidence for two forms of Crohn disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 64 citations in OpenAlex.
- Molecular dynamics study of the helix-to-disorder transition in short antimicrobial peptides from Urodacus yaschenkoi.European biophysics journal : EBJ · 2025Article
- Clinical Disease States Related to Mutations of the NOD2 Gene: A Case Report and Literature Review.Cureus · 2023Article
- Pharmacogenetic biomarkers of response in Crohn's disease.The pharmacogenomics journal · 2018Review
- PI3K/Akt/mTOR signaling & its regulator tumour suppressor genesThe Indian journal of medical research · 2016Article
- Article
- Disseminated aseptic abscesses associated with Crohn's disease: a new entity?Digestive diseases and sciences · 1998Article
- Interleukin-2 fusion protein (DAB389IL-2) selectively targets activated human peripheral blood and lamina propria lymphocytes.Digestive diseases and sciences · 1997Article
- Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease.Digestive diseases and sciences · 1997Article
- On the etiology of Crohn disease.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.The American journal of pathology · 1996Article
- Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR).Clinical and experimental immunology · 1995Article
- Clinical subtypes of Crohn's disease according to surgical outcome.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent epidemiological evidence suggests that there are two forms of Crohn disease (CD): perforating and nonperforating. We hypothesized that, just as with tuberculoid and lepromatous leprosy, differences in the two forms of CD would be both identified and determined by differences in the host immune response. Resected intestinal tissue from control patients as well as perforating and nonperforating CD patients was evaluated for mRNA levels. We employed 32P PCR amplification with published or custom-designed primers of a housekeeping gene (beta-actin); a human T-cell marker (CD3-delta); and the cytokines tumor necrosis factor alpha, transforming growth factor beta, granulocyte/macrophage colony-stimulating factor, interleukin (IL) 1 beta, IL-1ra, and IL-6. Differences were identified with IL-1 beta (control = 162 +/- 57 vs. perforating = 464 +/- 154 vs. nonperforating = 12,582 +/- 4733; P < or = 0.02) and IL-1ra (control = 1337 +/- 622 vs. perforating = 2194 +/- 775 vs. nonperforating = 9715 +/- 2988; P < or = 0.02). These data corroborate the epidemiological observation that there are two forms of CD. Nonperforating CD, the more benign form, is associated with increased IL-1 beta and IL-1ra mRNA expression. We conclude that it is the host immune response that determines which form of CD becomes manifest in any given individual and discuss the investigative, diagnostic, and therapeutic implications of these observations.
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