ArticleProceedings of the National Academy of Sciences of the United States of America1994
Transcriptional induction of Ty recombination in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Transcript RNA supports precise repair of its own DNA gene.RNA biology · 2016Article
- Article
- Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells.Molecular and cellular biology · 2006Article
- Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast.Molecular and cellular biology · 2004Article
- Article
- Transcription-dependent recombination and the role of fork collision in yeast rDNA.Genes & development · 2003Article
- Transcription and double-strand breaks induce similar mitotic recombination events in Saccharomyces cerevisiae.Genetics · 2002Article
- Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae.Genetics · 2002Article
- The connection between transcription and genomic instability.The EMBO journal · 2002Review
- Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Article
- A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.Genetics · 2001Article
- A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.The EMBO journal · 2000Article
- Stimulation of mitotic recombination events by high levels of RNA polymerase II transcription in yeast.Molecular and cellular biology · 2000Article
- The Saccharomyces cerevisiae DNA recombination and repair functions of the RAD52 epistasis group inhibit Ty1 transposition.Genetics · 2000Article
- Article
- cDNA of the yeast retrotransposon Ty5 preferentially recombines with substrates in silent chromatin.Molecular and cellular biology · 1999Article
- A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.The EMBO journal · 1998Article
- The involvement of cellular recombination and repair genes in RNA-mediated recombination in Saccharomyces cerevisiae.Genetics · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Families of repeated sequences are present in the genomes of all eukaryotes. Little is known about the mechanism(s) that prevents recombination between repeated sequences. In the yeast Saccharomyces cerevisiae, recombination between homologous sequences placed at nonhomologous locations in the genome (ectopic recombination) has been shown to occur at high frequencies for artificially created repeats, but at relatively low frequencies for a natural family of repeated sequences, the Ty family. We have previously shown that a high level of Ty cDNA in the cell causes an increase in the rate of nonreciprocal recombination (gene conversion) of a marked Ty element. In the present study, we show that it is also possible to elevate the rate of recombination of a marked Ty by increasing its transcription. This induction is different from, and acts synergistically to, the one seen upon increased levels of donor Ty cDNA. We show that the induction by transcription does not require the products of the RAD50, RAD51, and RAD57 genes. In contrast, cDNA-mediated recombination is dependent on the product of the RAD51 gene but not on products of the genes RAD50 or RAD57.
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