ArticleProceedings of the National Academy of Sciences of the United States of America1994
A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis.bioRxiv : the preprint server for biology · 2025Article
- Xrp1 governs the stress response program to spliceosome dysfunction.Nucleic acids research · 2024Article
- Paternal Induction of Hybrid Dysgenesis inG3 (Bethesda, Md.) · 2017Article
- Review
- Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- DNA transposon-based gene vehicles - scenes from an evolutionary drive.Journal of biomedical science · 2013Review
- Long-term and short-term evolutionary impacts of transposable elements on Drosophila.Genetics · 2012Article
- Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells.Journal of virology · 2007Article
- Article
- Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.Molecular and cellular biology · 2005Article
- Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells.Molecular and cellular biology · 2003Article
- Distinct P-element excision products in somatic and germline cells of Drosophila melanogaster.Genetics · 2000Article
- The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage.Molecular and cellular biology · 1999Article
- I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila.Genetics · 1999Article
- Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4.The EMBO journal · 1998Article
- DNA binding by the KP repressor protein inhibits P-element transposase activity in vitro.The EMBO journal · 1998Article
- Transposon Tc1 of the nematode Caenorhabditis elegans jumps in human cells.Nucleic acids research · 1998Article
- Transposition of the mariner element from Drosophila mauritiana in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
P transposable elements in Drosophila are mobilized via a cut-and-paste mechanism. This mode of transposition requires repair of both a double-strand break at the donor DNA site and gapped DNA at the target site. Biochemical studies have identified a cellular non-P element-encoded DNA binding protein, termed the inverted repeat binding protein (IRBP), that specifically interacts with the outer half of the 31-bp terminal inverted repeats. Protein sequence information was used to isolate cDNA clones encoding IRBP. Sequence analysis shows that IRBP is related to the 70-kDa subunit of the human Ku autoimmune antigen. The mammalian Ku antigen binds free DNA termini and has been implicated in immunoglobulin VDJ recombination, DNA repair, and transcription. In addition, Ku is the DNA binding subunit of the double-strand DNA-dependent protein kinase. Cytogenetic mapping indicates that the IRBP gene maps to chromosomal position 86E on the right arm of the third chromosome.
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