ArticleProceedings of the National Academy of Sciences of the United States of America1994
Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos.Communications biology · 2024Article
- Homeotic and nonhomeotic patterns in the tetrapod vertebral formula.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Breaking the constraint on the number of cervical vertebrae in mammals: On homeotic transformations in lorises and pottos.Evolution & development · 2022Article
- HOX-Gene Cluster Organization and Genome Duplications in Fishes and Mammals: Transcript Variant Distribution along the Anterior-Posterior Axis.International journal of molecular sciences · 2022Review
- Article
- Exploring copy number variants in deceased fetuses and neonates with abnormal vertebral patterns and cervical ribs.Birth defects research · 2020Article
- Article
- Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity.EMBO reports · 2020Article
- Cervical ribs and other abnormalities of the vertebral pattern in children with esophageal atresia and anorectal malformations.Pediatric research · 2020Article
- Etiology of Hypospadias: A Comparative Review of Genetic Factors and Developmental Processes Between Human and Animal Models.Research and reports in urology · 2020Review
- Hypomethylation of HOXA4 promoter is common in Silver-Russell syndrome and growth restriction and associates with stature in healthy children.Scientific reports · 2017Article
- Correlation betweenZoological letters · 2017Article
- Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression.Scientific reports · 2016Article
- Hoxa5: A Key Player in Development and Disease.Journal of developmental biology · 2016Review
- Correlation between Hox code and vertebral morphology in archosaurs.Proceedings. Biological sciences · 2015Article
- Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.PloS one · 2015Article
- Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.Nucleic acids research · 2014Article
- Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal.BMC genetics · 2013Article
- HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.The Journal of clinical investigation · 2013Article
- Hox targets and cellular functions.Scientifica · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hoxa-4 (previously known as Hox-1.4) is a mouse homeobox-containing gene that is expressed in the presumptive hindbrain and spinal cord, prevertebrae, and other tissues during embryogenesis. To understand the role of Hoxa-4 during development, we generated Hoxa-4 mutant mice. Homozygous mutants were viable and fertile. Analysis of neonatal skeletons revealed the development of ribs on the seventh cervical vertebra at variable penetrance and expressivity. A low frequency of alterations in sternal morphogenesis was also observed. In addition, we analyzed the skeletons of transgenic mice that overexpress Hoxa-4 and found that the formation of the small rib anlagen that often develop on the seventh cervical vertebra was suppressed. Analysis of adult homozygous mutant skeletons revealed that the dorsal process normally associated with the second cervical vertebra was also found on the third cervical vertebra. These results demonstrate that Hoxa-4 plays a role in conferring positional information along the anteroposterior axis to specify the identity of the third and the seventh cervical vertebrae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.