ArticleProceedings of the National Academy of Sciences of the United States of America1994
Binding of Vav to Grb2 through dimerization of Src homology 3 domains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 110 citations in OpenAlex.
- Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells.Frontiers in immunology · 2025Article
- Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.Scientific reports · 2017Article
- Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Oncotarget · 2015Review
- Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.Science signaling · 2011Article
- Studies of novel interactions between Nck and VAV SH3 domains.Communicative & integrative biology · 2011Article
- Cooperative interactions at the SLP-76 complex are critical for actin polymerization.The EMBO journal · 2010Article
- CD28 co-signaling in the adaptive immune response.Self/nonself · 2010Article
- Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.Seminars in cancer biology · 2008Review
- Neutral evolution of protein-protein interactions: a computational study using simple models.BMC structural biology · 2007Article
- An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand.Cell communication and signaling : CCS · 2006Article
- Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Experimental cell research · 2005Article
- Article
- SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.Molecular biology of the cell · 2004Article
- Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain.Journal of biomolecular NMR · 2002Article
- Vav proteins, adaptors and cell signaling.Oncogene · 2001Review
- Novel recognition mode between Vav and Grb2 SH3 domains.The EMBO journal · 2001Article
- Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.Molecular and cellular biology · 2000Article
- Article
- Vav family proteins couple to diverse cell surface receptors.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation. Here we report that both in cell extracts and within intact mammalian cells Vav binds to Grb2 (Sem-5/ASH/Drk), an adaptor molecule which plays a key role in Ras activation. The interaction became evident from a yeast two-hybrid screen and its specificity was demonstrated by in vitro binding assays. It is mediated by an unusual protein-protein binding reaction: dimerization of specific intact Src homology 3 domains of each of the partners. Signaling during hematopoietic lineage differentiation may therefore involve the tissue-specific signal transducer Vav linking into the ubiquitous pathway involving Grb2 and ultimately Ras.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.