ArticleProceedings of the National Academy of Sciences of the United States of America1994
Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- What Targets Somatic Hypermutation to the Immunoglobulin Loci?Viral immunology · 2020Review
- Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.Nature communications · 2018Article
- JMolecular immunology · 2018Article
- Does DNA repair occur during somatic hypermutation?Seminars in immunology · 2012Review
- Article
- Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion.The EMBO journal · 2007Article
- The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.The EMBO journal · 2001Article
- DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation.Genetics · 2001Article
- DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.The EMBO journal · 2000Article
- A human immunoglobulin lambda locus is similarly well expressed in mice and humans.The Journal of experimental medicine · 1999Article
- Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Journal of immunology (Baltimore, Md. : 1950) · 1999Article
- Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Both DNA strands of antibody genes are hypermutation targets.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.The Journal of experimental medicine · 1998Article
- Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements.Immunology · 1998Article
- Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.Nucleic acids research · 1997Article
- Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- An immunoglobulin mutator that targets G.C base pairs.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate and nature of hypermutation of immunoglobulin genes are of prime importance in the affinity maturation of antibodies. Although a considerable body of information has been gathered for kappa light chains, there is much less data for lambda chains. We have derived a large data base of somatic mutants of mouse lambda 1 light chains from Peyer's patches germinal center B cells. The endogenous lambda 1 genes mutate at a rate comparable to that previously found for a kappa transgene (V kappa ox1). There are intrinsic hot spots of mutation common to both in-frame and out-of-frame rearrangements; these hot spots cluster in hypermutating domains. In contrast to the pattern seen for V kappa Ox1, the hot spot clusters are found not only in complementarity-determining region (CDR)1 but also in CDR2 and CDR3; mutations also cluster in the joining/constant region intron. The differences between the pattern of mutations in V kappa Ox1 and lambda 1 light chains are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.