ReviewMolecular and cellular biochemistry
Creatine metabolism and the consequences of creatine depletion in muscle.
Review in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 104 citations in OpenAlex.
- One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease.Molecular syndromology · 2026Review
- Creatine supplementation and exercise in aging: a narrative review of the muscle-brain axis and its impact on cognitive and physical health.Frontiers in nutrition · 2025Review
- Combined targeted and untargeted high-resolution mass spectrometry analyses to investigate metabolic alterations in pompe disease.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Addition of a combination of creatine, carnitine, and choline to a commercial diet increases postprandial plasma creatine and creatinine concentrations in adult dogs.Frontiers in veterinary science · 2022Article
- Brain type of creatine kinase induces doxorubicin resistance via TGF-β signaling in MDA-MB-231 breast cancer cells.Animal cells and systems · 2022Article
- Comparison of Global Metabolite for Growing Pigs Fed at Metabolizable Energy Requirement for Maintenance.Frontiers in veterinary science · 2022Article
- Creatine as a Candidate to Prevent Statin Myopathy.Biomolecules · 2019Review
- Metabolic Profile of Oral Squamous Carcinoma Cell Lines Relies on a Higher Demand of Lipid Metabolism in Metastatic Cells.Frontiers in oncology · 2018Article
- Fifteen-year follow-up of Italian families affected by arginine glycine amidinotransferase deficiency.Orphanet journal of rare diseases · 2017Article
- Amino acids and derivatives, a new treatment of chronic heart failure?Heart failure reviews · 2015Review
- Creatine metabolism differs between mammals and rainbow trout (Oncorhynchus mykiss).SpringerPlus · 2014Article
- Integrating muscle cell biochemistry and whole-body physiology in humans:(31)P-MRS data from the InSight trial.Scientific reports · 2013Article
- Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?Neuroscience and biobehavioral reviews · 2012Review
- A potential role for creatine in drug abuse?Molecular neurobiology · 2011Review
- The creatine kinase system and pleiotropic effects of creatine.Amino acids · 2011Review
- Heart in diabetes: not only a macrovascular disease.Diabetes care · 2011Article
- Article
- Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy.Biological psychiatry · 2010Article
- Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology.Molecular and cellular biochemistry · 2007Article
- The management of conditioned nutritional requirements in heart failure.Heart failure reviews · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, considerable research activities are focussing on biochemical, physiological and pathological aspects of the creatine kinase (CK)-phosphorylcreatine (PCr)-creatine (Cr) system (for reviews see [1,2]), but only little effort is directed towards a thorough investigation of Cr metabolism as a whole. However, a detailed knowledge of Cr metabolism is essential for a deeper understanding of bioenergetics in general and, for example, of the effects of muscular dystrophies, atrophies, CK deficiencies (e.g. in transgenic animals) or Cr analogues on the energy metabolism of the tissues involved. Therefore, the present article provides a short overview on the reactions and enzymes involved in Cr biosynthesis and degradation, on the organization and regulation of Cr metabolism within the body, as well as on the metabolic consequences of 3-guanidinopropionate (GPA) feeding which is known to induce a Cr deficiency in muscle. In addition, the phenotype of muscles depleted of Cr and PCr by GPA feeding is put into context with recent investigations on the muscle phenotype of 'gene knockout' mice deficient in the cytosolic muscle-type M-CK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.