ReviewMolecular and cellular biochemistry
The creatine kinase system in smooth muscle.
Review in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The predictors of no reflow phenomenon after percutaneous coronary intervention in patients with ST elevation myocardial infarction: A meta-analysis.Indian heart journal · 2018Pooled it
- Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A systematic review.BMC medicine · 2013Pooled it
- Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.International journal of legal medicine · 2025Article
- Modified creatine greatly increases the performance of skeletal and smooth muscles.Biochemistry and biophysics reports · 2025Article
- Effect of the Lactation Phases on the Amplitude of Variation in Blood Serum Steroid Hormones and Some Hematochemical Analytes in Three Dairy Cow Breeds.Animals : an open access journal from MDPI · 2024Article
- Serum Cardiac and Skeletal Muscle Marker Changes in Repetitive Breath-hold Diving.Sports medicine - open · 2021Article
- Creatine kinase, energy reserve, and hypertension: from bench to bedside.Annals of translational medicine · 2018Review
- Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain.Neurochemical research · 2018Article
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- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- The creatine kinase system and pleiotropic effects of creatine.Amino acids · 2011Review
- Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome.World journal of gastroenterology · 2009Article
- Low creatine kinase is associated with a high population incidence of fainting.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2009Article
- Hypertension risk in idiopathic hyperCKemia.Journal of neurology · 2008Article
- Origin of ATP for Ca2+-induced contraction in the guinea-pig femoral artery.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Functional coupling of creatine kinases in muscles: species and tissue specificity.Molecular and cellular biochemistry · 1998Article
- Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle.Molecular and cellular biochemistry · 1998Article
- The role of MgADP in force maintenance by dephosphorylated cross-bridges in smooth muscle: a flash photolysis study.Biophysical journal · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the energetic flux being much lower in smooth muscle compared to striated muscles (such as the heart and skeletal muscle) creatine kinase (CK) has been found present and active in all smooth muscles studied to date. A complete CK circuit has been identified, with CK found in the mitochondria, contractile elements, membrane pumps and the cytoplasm. CK isoenzymes are coupled to many cellular energetic processes and appears to be involved in energy production and consumption by acting as an energy transducer. The CK system responds to pathological insults and development (e.g., hypertrophy and gestation respectively) by changes in sub-cellular distribution localization, isoenzymes, and specific activity. The conclusion from these observations is that creatine kinase is intimately involved in the energetic system of smooth muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.