ArticleJournal of molecular evolution1994
On hypervariability at the reactive center of proteolytic enzymes and their inhibitors.
Article in Journal of molecular evolution, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- The trypsin inhibitor panulirin regulates the prophenoloxidase-activating system in the spiny lobster Panulirus argus.The Journal of biological chemistry · 2013Article
- Article
- Evolution of disintegrin cysteine-rich and mammalian matrix-degrading metalloproteinases: gene duplication and divergence of a common ancestor rather than convergent evolution.Journal of molecular evolution · 1996Article
- Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci.Journal of molecular evolution · 1995Article
- Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory.Journal of molecular evolution · 1995Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
The pattern of synonymous and nonsynonymous substitutions at the reactive center of proteases (kallikrein) and their inhibitors (alpha 1-antitrypsin and serpin) was examined. In the case of alpha 1-antitrypsin, the proportion of different nonsynonymous sites exceeds that of different synonymous sites at the reactive center for sequence pairs of recent duplication. The result indicates that the positive selection has operated after duplication to increase functional diversity. In the cases of kallikrein, serpin, and remote sequence pairs of alpha 1-antitrypsin, the proportion of different synonymous sites at the reactive center exceeds that of different synonymous sites at the remaining region. The result indicates that gene conversion followed by natural selection is working. On the whole, it is concluded that hypervariability of amino acids at the reactive center is generated by an interaction among natural selection, random genetic drift, point mutation, and gene conversion. Gene duplication may provide potential for them to interact.
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