ArticleThe Journal of experimental medicine1995
Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.EMBO molecular medicine · 2018Article
- Wanderings in biochemistry.The Journal of biological chemistry · 2014Article
- Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.Science signaling · 2013Article
- Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4.The Journal of experimental medicine · 2008Article
- PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.The EMBO journal · 2001Article
- The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.The Journal of experimental medicine · 1998Article
- MAPkinase: a second site of G-protein regulation of B-cell activation via the antigen receptors.Immunology · 1998Article
- Notch inhibition of E47 supports the existence of a novel signaling pathway.Molecular and cellular biology · 1998Article
- Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background.The Journal of experimental medicine · 1997Article
- Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.Molecular and cellular biology · 1997Article
- Induction of the early growth response (Egr) family of transcription factors during thymic selection.The Journal of experimental medicine · 1997Article
- Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.The Biochemical journal · 1996Article
- Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes.Molecular and cellular biology · 1996Article
- Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1.The Journal of experimental medicine · 1996Article
- Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.The Biochemical journal · 1995Article
- Molecular remodelling in hypertrophied hearts from polyomavirus large T-antigen transgenic mice.Molecular and cellular biochemistry · 1995Article
- p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.Cytokine & growth factor reviewsReview
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2 authors at 1 institution in 1 country.
Funding
Abstract
The primary response gene egr-1 encodes a sequence-specific transcription factor whose expression is necessary for antigen receptor-stimulated activation of B lymphocytes. The molecular processes involved in linking egr-1 induction to antigen receptor signaling have not been defined. The present study demonstrates that expression of an activated form of p21ras results in egr-1 induction similar to that previously shown after antigen receptor cross-linking. In addition, both antigen receptor cross-linking and p21ras use the same element in the egr-1 promoter to exert their effects. Using dominant-negative mutants of p21ras and raf-1, we demonstrate that induction of egr-1 after antigen receptor cross-linking is mediated by activation of the p21ras/mitogen-activated protein kinase signaling pathway. While regulation of the p21ras pathway during B cell activation has been intensively studied, this report represents the first description of a biologically relevant event associated with its activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.