ArticleThe Journal of cell biology1994
Functional differences between L- and T-plastin isoforms.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 95 citations in OpenAlex.
- Bayesian Genome-Wide Association Study of Feed Efficiency Traits in Pigs.Animals : an open access journal from MDPI · 2026Article
- Actin Bundles Dynamics and Architecture.Biomolecules · 2023Review
- Getting cells into shape by calcium-dependent actin cross-linking proteins.Frontiers in cell and developmental biology · 2023Review
- L-Plastin Phosphorylation: Possible Regulation by a TNFR1 Signaling Cascade in Osteoclasts.Cells · 2021Article
- T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration.Nature communications · 2020Article
- L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction.Bone research · 2020Article
- LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.Journal of cell science · 2018Article
- L-plastin phosphorylation regulates the early phase of sealing ring formation by actin bundling process in mouse osteoclasts.Experimental cell research · 2018Article
- Article
- Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome.The Journal of investigative dermatology · 2015Article
- Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons.Human molecular genetics · 2014Article
- A common gene variant in PLS3 predicts colon cancer recurrence in women.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival.Genome medicine · 2012Article
- Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia.The Journal of cell biology · 2010Article
- The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.PloS one · 2010Article
- Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.PloS one · 2010Article
- Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.Molecular biology of the cell · 2009Article
- Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo.Development (Cambridge, England) · 2007Article
- Villin severing activity enhances actin-based motility in vivo.Molecular biology of the cell · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fimbrins/plastins are a family of highly conserved actin-bundling proteins. They are present in all eukaryotic cells including yeast, but each isoform displays a remarkable tissue specificity. T-plastin is normally found in epithelial and mesenchymal cells while L-plastin is present in hematopoietic cells. However, L-plastin has been also found in tumor cells of non-hematopoietic origin (Lin, C.-S., R. H. Aebersold, S. B. Kent, M. Varma, and J. Leavitt. 1988. Mol. Cell. Biol. 8:4659-4668; Lin, C.-S., R. H. Aebersold, and J. Leavitt. 1990. Mol. Cell. Biol. 10: 1818-1821). To learn more about the biological significance of their tissue specificity, we have overproduced the T- and L-plastin isoforms in a fibroblast-like cell line, CV-1, and in a polarized epithelial cell line, LLC-PK1. In CV-1 cells, overproduction of T- and L-plastins induces cell rounding and a concomitant reorganization of actin stress fibers into geodesic structures. L-plastin remains associated with microfilaments while T-plastin is almost completely extracted after treatment of the cells with non-ionic detergent. In LLC-PK1 cells, T-plastin induces shape changes in microvilli and remains associated with microvillar actin filaments after detergent extraction while L-plastin has no effect on these structures and is completely extracted. The effect of T-plastin on the organization of microvilli differs from that of villin, another actin-bundling protein. Our experiments indicate that these two isoforms play differing roles in actin filament organization, and do so in a cell type-specific fashion. Thus it is likely that these plastin isoforms play fundamentally different roles in cell function.
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