ArticleInfection and immunity1995
Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Enoyl-coenzyme A hydratase and antigen 85B of Mycobacterium habana are specifically recognized by antibodies in sera from leprosy patients.Clinical and vaccine immunology : CVI · 2011Article
- In infertile women, cells from Chlamydia trachomatis infected sites release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat-shock-protein stimulation than fertile women.Reproductive biology and endocrinology : RB&E · 2008Article
- Article
- Possible association of GroES and antigen 85 proteins with heat resistance of Mycobacterium paratuberculosis.Applied and environmental microbiology · 2004Article
- Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.Clinical and diagnostic laboratory immunology · 2001Article
- Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease.Infection and immunity · 2000Article
- Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects.Clinical and experimental immunology · 1999Article
- Chlamydial heat shock proteins and disease pathology: new paradigms for old problems?Infectious diseases in obstetrics and gynecology · 1999Review
- Leprosy patients with lepromatous disease recognize cross-reactive T cell epitopes in the Mycobacterium leprae 10-kD antigen.Clinical and experimental immunology · 1998Article
- T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.Infection and immunity · 1998Article
- Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10.Journal of clinical microbiology · 1997Article
- A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae.Infection and immunity · 1996Article
- Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.Infection and immunity · 1996Article
- The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral blood mononuclear cells from 27 healthy leprosy contacts were analyzed for lymphoproliferation and TH-1 cytokine secretion (interleukin-2 and gamma interferon) in response to heat shock proteins with molecular masses of 65, 18, and 10 kDa from Mycobacterium leprae and the 30-32-kDa antigen 85 (Ag 85) from Mycobacterium bovis BCG. Cells from 18 and 19 of 19 lepromin-positive contacts proliferated or produced TH-1 cytokines in response to the M. leprae 10-kDa protein and to Ag 85, respectively. Limiting-dilution analysis for two lepromin-positive contacts indicated that about one-third of M. leprae-reactive T cells displayed specificity to the M. leprae 10-kDa protein and Ag 85. The M. leprae 65- and 18-kDa proteins were less potent TH-1 response inducers: gamma interferon and interleukin-2 could be measured in 14 and 19 lepromin-positive contacts, respectively. In contrast, very low or undetectable proliferative and cytokine responses were found for 8 lepromin-negative contacts. Our data demonstrate that the fibronectin-binding Ag 85 and the 10-kDa GroES homolog are powerful mycobacterial TH-1 response inducers in the vast majority of lepromin-positive contacts and suggest that they might be valuable candidates for a future subunit vaccine.
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