ArticleImmunogenetics1995
A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 37 citations in OpenAlex.
- Downregulation ofAnnals of translational medicine · 2019Article
- VARS2 V552V variant as prognostic marker in patients with early breast cancer.Medical oncology (Northwood, London, England) · 2011Article
- Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.Oncogene · 2001Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Lung tumor susceptibility (LTS) in the mouse is influenced by multiple loci within the H2 complex. We compared the LTS of two H2 congenic strains with intra H2 recombinations, B10.A(1R) and B10.A(2R), whose genetic difference has been reduced to a region of approximately 50 kilobases within the C4-H2D interval, between Hsp70.3 and G7. After transplacental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10.A(2R) is significantly higher than in strain B10.A(1R) (P < 0.001). For papillary tumors no significant differences were observed. We conclude that the alveolar lung tumor load is influenced by an LTS gene located within the Hsp70.3-G7 interval.
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