ArticleNucleic acids research1994
Alu repeated DNAs are differentially methylated in primate germ cells.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 104 citations in OpenAlex.
- Sperm AluY Epimutations in Male Partners of Couples with Unexplained Recurrent Pregnancy Loss.bioRxiv : the preprint server for biology · 2026Article
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis.Frontiers in oncology · 2019Review
- Whole-genome bisulfite sequencing maps from multiple human tissues reveal novel CpG islands associated with tissue-specific regulation.Human molecular genetics · 2016Article
- DNA methylation variation of human-specific Alu repeats.Epigenetics · 2016Article
- Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms.Nature communications · 2015Article
- Article
- Functional microRNAs and target sites are created by lineage-specific transposition.Human molecular genetics · 2014Article
- Bidirectional promoters as important drivers for the emergence of species-specific transcripts.PloS one · 2013Article
- The origin of the RB1 imprint.PloS one · 2013Article
- Article
- Epigenetic regulation of human embryonic stem cells.Frontiers in genetics · 2012Article
- LINEs, SINEs and other retroelements: do birds of a feather flock together?Frontiers in bioscience (Landmark edition) · 2012Review
- Origin and evolution of SINEs in eukaryotic genomes.Heredity · 2011Review
- Human piRNAs are under selection in Africans and repress transposable elements.Molecular biology and evolution · 2011Article
- The (r)evolution of SINE versus LINE distributions in primate genomes: sex chromosomes are important.Genome research · 2010Article
- Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas.BMC cancer · 2010Article
- The impact of retrotransposons on human genome evolution.Nature reviews. Genetics · 2009Review
- Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.PLoS genetics · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A significant fraction of Alu repeats in human sperm DNA, previously found to be unmethylated, is nearly completely methylated in DNA from many somatic tissues. A similar fraction of unmethylated Alus is observed here in sperm DNA from rhesus monkey. However, Alus are almost completely methylated at the restriction sites tested in monkey follicular oocyte DNA. The Alu methylation patterns in mature male and female monkey germ cells are consistent with Alu methylation in human germ cell tumors. Alu sequences are hypomethylated in seminoma DNAs and more methylated in a human ovarian dysgerminoma. These results contrast with methylation patterns reported for germ cell single-copy, CpG island, satellite, and L1 sequences. The function of Alu repeats is not known, but differential methylation of Alu repeats in the male and female germ lines suggests that they may serve as markers for genomic imprinting or in maintaining differences in male and female meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.