ArticleNucleic acids research1994
Replication fork barriers in the Xenopus rDNA.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Ribosomal DNA instability and genome adaptability.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Review
- Nucleolar dominance and maternal control of 45S rDNA expression.Proceedings. Biological sciences · 2015Article
- Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control.Genes & cancer · 2012Article
- DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.Genes & development · 2012Article
- Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery.Nucleic acids research · 2011Article
- Can eukaryotic cells monitor the presence of unreplicated DNA?Cell division · 2007Article
- Replication fork stalling at natural impediments.Microbiology and molecular biology reviews : MMBR · 2007Review
- Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex.Molecular and cellular biology · 2006Article
- The mating type switch-activating protein Sap1 Is required for replication fork arrest at the rRNA genes of fission yeast.Molecular and cellular biology · 2005Article
- Impairment of replication fork progression mediates RNA polII transcription-associated recombination.The EMBO journal · 2005Article
- swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Transcription termination factor reb1p causes two replication fork barriers at its cognate sites in fission yeast ribosomal DNA in vivo.Molecular and cellular biology · 2004Article
- Complex mechanism of site-specific DNA replication termination in fission yeast.The EMBO journal · 2003Article
- A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombe.Genes & development · 2001Article
- Architecture of the replication fork stalled at the 3' end of yeast ribosomal genes.Molecular and cellular biology · 2000Article
- Ribosomal DNA replication fork barrier and HOT1 recombination hot spot: shared sequences but independent activities.Molecular and cellular biology · 2000Article
- Interference of the simian virus 40 origin of replication by the cytomegalovirus immediate early gene enhancer: evidence for competition of active regulatory chromatin conformation in a single domain.Molecular and cellular biology · 2000Article
- Characterization of the pea rDNA replication fork barrier: putative cis-acting and trans-acting factors.Plant molecular biology · 1999Article
- Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I.Genes & development · 1998Article
- Bacteriophage phi29 DNA replication arrest caused by codirectional collisions with the transcription machinery.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate replication fork progression along the tandemly repeated rRNA genes of Xenopus laevis and Xenopus borealis, rDNA replication intermediates from dividing tissue culture cells were analyzed by two-dimensional gel electrophoresis. Analysis of the direction of replication in the rRNA coding regions revealed replication forks moving in both directions. However, in both frog species, polar replication fork barriers (RFB) arresting forks approaching the rRNA transcription units from downstream were identified. Whereas in X. borealis the RFB maps to a defined site close to the transcription terminator, in X. laevis the arrest of fork movement can occur at multiple positions throughout a 3' flanking repetitive spacer region. A short DNA element located near the respective RFB sites is shared between these two related frog species, suggesting its possible involvement in the arrest of replication fork movement. In a subset of rDNA repeats, these barriers cause an absolute block to replication fork progression, defining the sites where replicon fusion occurs, whereas in the remainder repeats, most probably in the non-transcribed gene copies, the replication machinery can pass the RFB sequences and replicate the rRNA transcription unit in a 3'-to-5' direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.