ArticleNucleic acids research1994
Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
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- Gbp2 interacts with THO/TREX through a novel type of RRM domain.Nucleic acids research · 2016Article
- Identification of TTAGGG-binding proteins in Neurospora crassa, a fungus with vertebrate-like telomere repeats.BMC genomics · 2015Article
- Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.Genes & development · 2010Review
- Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.Infection and immunity · 2010Article
- POT1-independent single-strand telomeric DNA binding activities in Brassicaceae.The Plant journal : for cell and molecular biology · 2009Article
- The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein.The Biochemical journal · 2007Article
- Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.PLoS genetics · 2006Article
- Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.Molecular and cellular biology · 2004Article
- Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control.Nucleic acids research · 2004Article
- Biogenesis of yeast telomerase depends on the importin mtr10.Molecular and cellular biology · 2002Article
- Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.The EMBO journal · 2001Article
- Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.Nucleic acids research · 2000Article
- Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.Nucleic acids research · 2000Article
- The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Molecular and cellular biology · 2000Article
- Gbp1p, a protein with RNA recognition motifs, binds single-stranded telomeric DNA and changes its binding specificity upon dimerization.Molecular and cellular biology · 1999Article
- Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo.Molecular and cellular biology · 1998Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
By screening lambda gt11 libraries with a radiolabeled (TG1-3)n oligonucleotide, two Saccharomyces cerevisiae genes were identified that encode polypeptides that recognize the single-stranded telomeric repeat sequence (TG1-3)n. The first gene, NSR1, a previously identified gene, encodes a protein involved in ribosomal RNA maturation and possibly in transport of proteins into the nucleus. The second gene, GBP2 (G-strand Binding Protein), is an anonymous open reading frame from chromosome III. These two genes contain RNA recognition motifs (RRMs) that are found in proteins that interact with RNA. Both Nsr1p and Gbp2p bind specifically to yeast single strand (TG1-3)n DNA in vitro. To test whether these two proteins associate with telomeres in vivo, strains were constructed in which one or both of these genes were either disrupted or overexpressed. None of these alterations affected telomere length or telomere position effect. The potential role of these two (TG1-3)n binding proteins is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.