ReviewNeurochemical research1994
Expression and biological functions of sulfoglucuronyl glycolipids (SGGLs) in the nervous system--a review.
Review in Neurochemical research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 114 citations in OpenAlex.
- Analysis of Lacto/Neolacto-Series Glycolipids and Gangliosides.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Does Altered Membrane Glycosylation Contribute to Neurodevelopmental Dysfunction in Autism Spectrum Disorder?Membranes · 2026Review
- Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder.International journal of molecular sciences · 2023Article
- Glycosphingolipids in human embryonic stem cells and breast cancer stem cells, and potential cancer therapy strategies based on their structures and functions.Glycoconjugate journal · 2022Review
- Proteins Binding to the Carbohydrate HNK-1: Common Origins?International journal of molecular sciences · 2021Article
- B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas.CNS neuroscience & therapeutics · 2020Article
- Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights.Cellular and molecular life sciences : CMLS · 2019Review
- Glycosylation Changes in Brain Cancer.ACS chemical neuroscience · 2018Review
- The Adhesion Molecule-Characteristic HNK-1 Carbohydrate Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish.Molecular neurobiology · 2017Article
- Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2.Stem cells translational medicine · 2012Article
- Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis.The Journal of biological chemistry · 2012Article
- Detection and characterization of a novel subset of CD8⁺CD57⁺ T cells in metastatic melanoma with an incompletely differentiated phenotype.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- The role of sulfoglucuronosyl glycosphingolipids in the pathogenesis of monoclonal IgM paraproteinemia and peripheral neuropathy.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Review
- PROCARB: A Database of Known and Modelled Carbohydrate-Binding Protein Structures with Sequence-Based Prediction Tools.Advances in bioinformatics · 2010Article
- Biomarkers in Acute Kidney Injury.Biomarker insights · 2008Article
- Regulation of sulfoglucuronyl glycolipid synthesis in the developing rat sciatic nerve.Neurochemical research · 2001Article
- Characterization and distribution of a new cell surface marker of neuronal precursors.Developmental neuroscience · 2000Article
- Paraproteinaemic neuropathies.Brain pathology (Zurich, Switzerland) · 1999Review
- alpha1,3 Fucosyltransferase, alpha-L-fucosidase, alpha-D-galactosidase, beta-D-galactosidase, and Le(x) glycoconjugates in developing rat brain.Glycoconjugate journal · 1998Article
- Gangliosides and glycosphingolipids of peripheral nervous system myelins--a minireview.Neurochemical research · 1998Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sulfoglucuronyl carbohydrate linked to neolactotetraose reacts with HNK-1 antibody. The HNK-1 carbohydrate epitope is found in two major glycolipids, several glycoproteins and in some proteoglycans of the nervous system. Most of the HNK-1 reactive glycoproteins so far identified are neural cell adhesion molecules and/or are involved in cell-cell interactions. HNK-1 carbohydrate is highly immunogenic. Several HNK-1-like antibodies, including IgM of some patients with plasma cell abnormalities and having peripheral neuropathy, have been described. This article summarizes published work mainly on sulfoglucuronyl glycolipids, SGGLs and covers: structural requirements of the carbohydrate epitope for binding to HNK-1 and human antibodies, expression of the lipids in various neural areas, stage and region specific developmental expression in CNS and PNS, immunocytochemical localization, loss of expression in Purkinje cell abnormality murine mutations, biosynthetic regulation of expression by a single enzyme N-acetylglucosaminyl transferase, identification of receptor-like carbohydrate binding neural proteins (lectins), and perceived role of the carbohydrate in physiological functions. The latter includes role in: pathogenesis of certain peripheral neuropathies, in migration of neural crest cells, as a ligand in cell-cell adhesion/interaction and as a promoter of neurite outgrowth for motor neurons. Multiple expression of HNK-1 carbohydrate in several molecules and in various neural cell types at specific stages of nervous system development has puzzled investigators as to its specific biological function, but this may also suggest its importance in multiple systems during cell differentiation and migration processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.